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Structural and Resting State Functional Connectivity of the Subthalamic Nucleus: Identification of Motor STN Parts and the Hyperdirect Pathway

Deep brain stimulation (DBS) for Parkinson’s disease often alleviates the motor symptoms, but causes cognitive and emotional side effects in a substantial number of cases. Identification of the motor part of the subthalamic nucleus (STN) as part of the presurgical workup could minimize these adverse...

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Autores principales: Brunenberg, Ellen J. L., Moeskops, Pim, Backes, Walter H., Pollo, Claudio, Cammoun, Leila, Vilanova, Anna, Janssen, Marcus L. F., Visser-Vandewalle, Veerle E. R. M., ter Haar Romeny, Bart M., Thiran, Jean-Philippe, Platel, Bram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387169/
https://www.ncbi.nlm.nih.gov/pubmed/22768059
http://dx.doi.org/10.1371/journal.pone.0039061
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author Brunenberg, Ellen J. L.
Moeskops, Pim
Backes, Walter H.
Pollo, Claudio
Cammoun, Leila
Vilanova, Anna
Janssen, Marcus L. F.
Visser-Vandewalle, Veerle E. R. M.
ter Haar Romeny, Bart M.
Thiran, Jean-Philippe
Platel, Bram
author_facet Brunenberg, Ellen J. L.
Moeskops, Pim
Backes, Walter H.
Pollo, Claudio
Cammoun, Leila
Vilanova, Anna
Janssen, Marcus L. F.
Visser-Vandewalle, Veerle E. R. M.
ter Haar Romeny, Bart M.
Thiran, Jean-Philippe
Platel, Bram
author_sort Brunenberg, Ellen J. L.
collection PubMed
description Deep brain stimulation (DBS) for Parkinson’s disease often alleviates the motor symptoms, but causes cognitive and emotional side effects in a substantial number of cases. Identification of the motor part of the subthalamic nucleus (STN) as part of the presurgical workup could minimize these adverse effects. In this study, we assessed the STN’s connectivity to motor, associative, and limbic brain areas, based on structural and functional connectivity analysis of volunteer data. For the structural connectivity, we used streamline counts derived from HARDI fiber tracking. The resulting tracks supported the existence of the so-called “hyperdirect” pathway in humans. Furthermore, we determined the connectivity of each STN voxel with the motor cortical areas. Functional connectivity was calculated based on functional MRI, as the correlation of the signal within a given brain voxel with the signal in the STN. Also, the signal per STN voxel was explained in terms of the correlation with motor or limbic brain seed ROI areas. Both right and left STN ROIs appeared to be structurally and functionally connected to brain areas that are part of the motor, associative, and limbic circuit. Furthermore, this study enabled us to assess the level of segregation of the STN motor part, which is relevant for the planning of STN DBS procedures.
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spelling pubmed-33871692012-07-05 Structural and Resting State Functional Connectivity of the Subthalamic Nucleus: Identification of Motor STN Parts and the Hyperdirect Pathway Brunenberg, Ellen J. L. Moeskops, Pim Backes, Walter H. Pollo, Claudio Cammoun, Leila Vilanova, Anna Janssen, Marcus L. F. Visser-Vandewalle, Veerle E. R. M. ter Haar Romeny, Bart M. Thiran, Jean-Philippe Platel, Bram PLoS One Research Article Deep brain stimulation (DBS) for Parkinson’s disease often alleviates the motor symptoms, but causes cognitive and emotional side effects in a substantial number of cases. Identification of the motor part of the subthalamic nucleus (STN) as part of the presurgical workup could minimize these adverse effects. In this study, we assessed the STN’s connectivity to motor, associative, and limbic brain areas, based on structural and functional connectivity analysis of volunteer data. For the structural connectivity, we used streamline counts derived from HARDI fiber tracking. The resulting tracks supported the existence of the so-called “hyperdirect” pathway in humans. Furthermore, we determined the connectivity of each STN voxel with the motor cortical areas. Functional connectivity was calculated based on functional MRI, as the correlation of the signal within a given brain voxel with the signal in the STN. Also, the signal per STN voxel was explained in terms of the correlation with motor or limbic brain seed ROI areas. Both right and left STN ROIs appeared to be structurally and functionally connected to brain areas that are part of the motor, associative, and limbic circuit. Furthermore, this study enabled us to assess the level of segregation of the STN motor part, which is relevant for the planning of STN DBS procedures. Public Library of Science 2012-06-29 /pmc/articles/PMC3387169/ /pubmed/22768059 http://dx.doi.org/10.1371/journal.pone.0039061 Text en Brunenberg et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Brunenberg, Ellen J. L.
Moeskops, Pim
Backes, Walter H.
Pollo, Claudio
Cammoun, Leila
Vilanova, Anna
Janssen, Marcus L. F.
Visser-Vandewalle, Veerle E. R. M.
ter Haar Romeny, Bart M.
Thiran, Jean-Philippe
Platel, Bram
Structural and Resting State Functional Connectivity of the Subthalamic Nucleus: Identification of Motor STN Parts and the Hyperdirect Pathway
title Structural and Resting State Functional Connectivity of the Subthalamic Nucleus: Identification of Motor STN Parts and the Hyperdirect Pathway
title_full Structural and Resting State Functional Connectivity of the Subthalamic Nucleus: Identification of Motor STN Parts and the Hyperdirect Pathway
title_fullStr Structural and Resting State Functional Connectivity of the Subthalamic Nucleus: Identification of Motor STN Parts and the Hyperdirect Pathway
title_full_unstemmed Structural and Resting State Functional Connectivity of the Subthalamic Nucleus: Identification of Motor STN Parts and the Hyperdirect Pathway
title_short Structural and Resting State Functional Connectivity of the Subthalamic Nucleus: Identification of Motor STN Parts and the Hyperdirect Pathway
title_sort structural and resting state functional connectivity of the subthalamic nucleus: identification of motor stn parts and the hyperdirect pathway
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387169/
https://www.ncbi.nlm.nih.gov/pubmed/22768059
http://dx.doi.org/10.1371/journal.pone.0039061
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