γ-H2AX Kinetics as a Novel Approach to High Content Screening for Small Molecule Radiosensitizers

BACKGROUND: Persistence of γ-H2AX after ionizing radiation (IR) or drug therapy is a robust reporter of unrepaired DNA double strand breaks in treated cells. METHODS: DU-145 prostate cancer cells were treated with a chemical library ±IR and assayed for persistence of γ-H2AX using an automated 96-wel...

Descripción completa

Detalles Bibliográficos
Autores principales: Fu, Shibo, Yang, Ying, Tirtha, Das, Yen, Yun, Zhou, Bing-sen, Zhou, Ming-Ming, Ohlmeyer, Michael, Ko, Eric C., Cagan, Ross, Rosenstein, Barry S., Chen, Shu-hsia, Kao, Johnny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387170/
https://www.ncbi.nlm.nih.gov/pubmed/22768044
http://dx.doi.org/10.1371/journal.pone.0038465

Ejemplares similares

Ejemplares similares