Intrathecal Injection of Spironolactone Attenuates Radicular Pain by Inhibition of Spinal Microglia Activation in a Rat Model

BACKGROUND: Microglia might play an important role in nociceptive processing and hyperalgesia by neuroinflammatory process. Mineralocorticoid receptor (MR) expressed on microglia might play a central role in the modulation of microglia activity. However the roles of microglia and MR in radicular pai...

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Detalles Bibliográficos
Autores principales: Sun, Yu-e, Peng, Liangyu, Sun, Xiaofeng, Bo, Jinhua, Yang, Dong, Zheng, Yaguo, Liu, Chenglong, Zhu, Beibei, Ma, Zhengliang, Gu, Xiaoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387194/
https://www.ncbi.nlm.nih.gov/pubmed/22768159
http://dx.doi.org/10.1371/journal.pone.0039897

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387194/
https://www.ncbi.nlm.nih.gov/pubmed/22768159
http://dx.doi.org/10.1371/journal.pone.0039897

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