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Intrathecal Injection of Spironolactone Attenuates Radicular Pain by Inhibition of Spinal Microglia Activation in a Rat Model
BACKGROUND: Microglia might play an important role in nociceptive processing and hyperalgesia by neuroinflammatory process. Mineralocorticoid receptor (MR) expressed on microglia might play a central role in the modulation of microglia activity. However the roles of microglia and MR in radicular pai...
Autores principales: | Sun, Yu-e, Peng, Liangyu, Sun, Xiaofeng, Bo, Jinhua, Yang, Dong, Zheng, Yaguo, Liu, Chenglong, Zhu, Beibei, Ma, Zhengliang, Gu, Xiaoping |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387194/ https://www.ncbi.nlm.nih.gov/pubmed/22768159 http://dx.doi.org/10.1371/journal.pone.0039897 |
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