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Simulated Evolution of Protein-Protein Interaction Networks with Realistic Topology

We model the evolution of eukaryotic protein-protein interaction (PPI) networks. In our model, PPI networks evolve by two known biological mechanisms: (1) Gene duplication, which is followed by rapid diversification of duplicate interactions. (2) Neofunctionalization, in which a mutation leads to a...

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Detalles Bibliográficos
Autores principales:	Peterson, G. Jack, Pressé, Steve, Peterson, Kristin S., Dill, Ken A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387198/ https://www.ncbi.nlm.nih.gov/pubmed/22768057 http://dx.doi.org/10.1371/journal.pone.0039052

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