Characterization of Coding Synonymous and Non-Synonymous Variants in ADAMTS13 Using Ex Vivo and In Silico Approaches

Synonymous variations, which are defined as codon substitutions that do not change the encoded amino acid, were previously thought to have no effect on the properties of the synthesized protein(s). However, mounting evidence shows that these “silent” variations can have a significant impact on prote...

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Detalles Bibliográficos
Autores principales: Edwards, Nathan C., Hing, Zachary A., Perry, Avital, Blaisdell, Adam, Kopelman, David B., Fathke, Robert, Plum, William, Newell, Jordan, Allen, Courtni E., S., Geetha, Shapiro, Aaron, Okunji, Chinyere, Kosti, Idit, Shomron, Noam, Grigoryan, Vahan, Przytycka, Teresa M., Sauna, Zuben E., Salari, Raheleh, Mandel-Gutfreund, Yael, Komar, Anton A., Kimchi-Sarfaty, Chava
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387200/
https://www.ncbi.nlm.nih.gov/pubmed/22768050
http://dx.doi.org/10.1371/journal.pone.0038864

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