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Chronic Exposure to Low Frequency Noise at Moderate Levels Causes Impaired Balance in Mice
We are routinely exposed to low frequency noise (LFN; below 0.5 kHz) at moderate levels of 60–70 dB sound pressure level (SPL) generated from various sources in occupational and daily environments. LFN has been reported to affect balance in humans. However, there is limited information about the inf...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387207/ https://www.ncbi.nlm.nih.gov/pubmed/22768129 http://dx.doi.org/10.1371/journal.pone.0039807 |
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author | Tamura, Haruka Ohgami, Nobutaka Yajima, Ichiro Iida, Machiko Ohgami, Kyoko Fujii, Noriko Itabe, Hiroyuki Kusudo, Tastuya Yamashita, Hitoshi Kato, Masashi |
author_facet | Tamura, Haruka Ohgami, Nobutaka Yajima, Ichiro Iida, Machiko Ohgami, Kyoko Fujii, Noriko Itabe, Hiroyuki Kusudo, Tastuya Yamashita, Hitoshi Kato, Masashi |
author_sort | Tamura, Haruka |
collection | PubMed |
description | We are routinely exposed to low frequency noise (LFN; below 0.5 kHz) at moderate levels of 60–70 dB sound pressure level (SPL) generated from various sources in occupational and daily environments. LFN has been reported to affect balance in humans. However, there is limited information about the influence of chronic exposure to LFN at moderate levels for balance. In this study, we investigated whether chronic exposure to LFN at a moderate level of 70 dB SPL affects the vestibule, which is one of the organs responsible for balance in mice. Wild-type ICR mice were exposed for 1 month to LFN (0.1 kHz) and high frequency noise (HFN; 16 kHz) at 70 dB SPL at a distance of approximately 10–20 cm. Behavior analyses including rotarod, beam-crossing and footprint analyses showed impairments of balance in LFN-exposed mice but not in non-exposed mice or HFN-exposed mice. Immunohistochemical analysis showed a decreased number of vestibular hair cells and increased levels of oxidative stress in LFN-exposed mice compared to those in non-exposed mice. Our results suggest that chronic exposure to LFN at moderate levels causes impaired balance involving morphological impairments of the vestibule with enhanced levels of oxidative stress. Thus, the results of this study indicate the importance of considering the risk of chronic exposure to LFN at a moderate level for imbalance. |
format | Online Article Text |
id | pubmed-3387207 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-33872072012-07-05 Chronic Exposure to Low Frequency Noise at Moderate Levels Causes Impaired Balance in Mice Tamura, Haruka Ohgami, Nobutaka Yajima, Ichiro Iida, Machiko Ohgami, Kyoko Fujii, Noriko Itabe, Hiroyuki Kusudo, Tastuya Yamashita, Hitoshi Kato, Masashi PLoS One Research Article We are routinely exposed to low frequency noise (LFN; below 0.5 kHz) at moderate levels of 60–70 dB sound pressure level (SPL) generated from various sources in occupational and daily environments. LFN has been reported to affect balance in humans. However, there is limited information about the influence of chronic exposure to LFN at moderate levels for balance. In this study, we investigated whether chronic exposure to LFN at a moderate level of 70 dB SPL affects the vestibule, which is one of the organs responsible for balance in mice. Wild-type ICR mice were exposed for 1 month to LFN (0.1 kHz) and high frequency noise (HFN; 16 kHz) at 70 dB SPL at a distance of approximately 10–20 cm. Behavior analyses including rotarod, beam-crossing and footprint analyses showed impairments of balance in LFN-exposed mice but not in non-exposed mice or HFN-exposed mice. Immunohistochemical analysis showed a decreased number of vestibular hair cells and increased levels of oxidative stress in LFN-exposed mice compared to those in non-exposed mice. Our results suggest that chronic exposure to LFN at moderate levels causes impaired balance involving morphological impairments of the vestibule with enhanced levels of oxidative stress. Thus, the results of this study indicate the importance of considering the risk of chronic exposure to LFN at a moderate level for imbalance. Public Library of Science 2012-06-29 /pmc/articles/PMC3387207/ /pubmed/22768129 http://dx.doi.org/10.1371/journal.pone.0039807 Text en Tamura et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Tamura, Haruka Ohgami, Nobutaka Yajima, Ichiro Iida, Machiko Ohgami, Kyoko Fujii, Noriko Itabe, Hiroyuki Kusudo, Tastuya Yamashita, Hitoshi Kato, Masashi Chronic Exposure to Low Frequency Noise at Moderate Levels Causes Impaired Balance in Mice |
title | Chronic Exposure to Low Frequency Noise at Moderate Levels Causes Impaired Balance in Mice |
title_full | Chronic Exposure to Low Frequency Noise at Moderate Levels Causes Impaired Balance in Mice |
title_fullStr | Chronic Exposure to Low Frequency Noise at Moderate Levels Causes Impaired Balance in Mice |
title_full_unstemmed | Chronic Exposure to Low Frequency Noise at Moderate Levels Causes Impaired Balance in Mice |
title_short | Chronic Exposure to Low Frequency Noise at Moderate Levels Causes Impaired Balance in Mice |
title_sort | chronic exposure to low frequency noise at moderate levels causes impaired balance in mice |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387207/ https://www.ncbi.nlm.nih.gov/pubmed/22768129 http://dx.doi.org/10.1371/journal.pone.0039807 |
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