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Chronic Exposure to Low Frequency Noise at Moderate Levels Causes Impaired Balance in Mice

We are routinely exposed to low frequency noise (LFN; below 0.5 kHz) at moderate levels of 60–70 dB sound pressure level (SPL) generated from various sources in occupational and daily environments. LFN has been reported to affect balance in humans. However, there is limited information about the inf...

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Autores principales: Tamura, Haruka, Ohgami, Nobutaka, Yajima, Ichiro, Iida, Machiko, Ohgami, Kyoko, Fujii, Noriko, Itabe, Hiroyuki, Kusudo, Tastuya, Yamashita, Hitoshi, Kato, Masashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387207/
https://www.ncbi.nlm.nih.gov/pubmed/22768129
http://dx.doi.org/10.1371/journal.pone.0039807
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author Tamura, Haruka
Ohgami, Nobutaka
Yajima, Ichiro
Iida, Machiko
Ohgami, Kyoko
Fujii, Noriko
Itabe, Hiroyuki
Kusudo, Tastuya
Yamashita, Hitoshi
Kato, Masashi
author_facet Tamura, Haruka
Ohgami, Nobutaka
Yajima, Ichiro
Iida, Machiko
Ohgami, Kyoko
Fujii, Noriko
Itabe, Hiroyuki
Kusudo, Tastuya
Yamashita, Hitoshi
Kato, Masashi
author_sort Tamura, Haruka
collection PubMed
description We are routinely exposed to low frequency noise (LFN; below 0.5 kHz) at moderate levels of 60–70 dB sound pressure level (SPL) generated from various sources in occupational and daily environments. LFN has been reported to affect balance in humans. However, there is limited information about the influence of chronic exposure to LFN at moderate levels for balance. In this study, we investigated whether chronic exposure to LFN at a moderate level of 70 dB SPL affects the vestibule, which is one of the organs responsible for balance in mice. Wild-type ICR mice were exposed for 1 month to LFN (0.1 kHz) and high frequency noise (HFN; 16 kHz) at 70 dB SPL at a distance of approximately 10–20 cm. Behavior analyses including rotarod, beam-crossing and footprint analyses showed impairments of balance in LFN-exposed mice but not in non-exposed mice or HFN-exposed mice. Immunohistochemical analysis showed a decreased number of vestibular hair cells and increased levels of oxidative stress in LFN-exposed mice compared to those in non-exposed mice. Our results suggest that chronic exposure to LFN at moderate levels causes impaired balance involving morphological impairments of the vestibule with enhanced levels of oxidative stress. Thus, the results of this study indicate the importance of considering the risk of chronic exposure to LFN at a moderate level for imbalance.
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spelling pubmed-33872072012-07-05 Chronic Exposure to Low Frequency Noise at Moderate Levels Causes Impaired Balance in Mice Tamura, Haruka Ohgami, Nobutaka Yajima, Ichiro Iida, Machiko Ohgami, Kyoko Fujii, Noriko Itabe, Hiroyuki Kusudo, Tastuya Yamashita, Hitoshi Kato, Masashi PLoS One Research Article We are routinely exposed to low frequency noise (LFN; below 0.5 kHz) at moderate levels of 60–70 dB sound pressure level (SPL) generated from various sources in occupational and daily environments. LFN has been reported to affect balance in humans. However, there is limited information about the influence of chronic exposure to LFN at moderate levels for balance. In this study, we investigated whether chronic exposure to LFN at a moderate level of 70 dB SPL affects the vestibule, which is one of the organs responsible for balance in mice. Wild-type ICR mice were exposed for 1 month to LFN (0.1 kHz) and high frequency noise (HFN; 16 kHz) at 70 dB SPL at a distance of approximately 10–20 cm. Behavior analyses including rotarod, beam-crossing and footprint analyses showed impairments of balance in LFN-exposed mice but not in non-exposed mice or HFN-exposed mice. Immunohistochemical analysis showed a decreased number of vestibular hair cells and increased levels of oxidative stress in LFN-exposed mice compared to those in non-exposed mice. Our results suggest that chronic exposure to LFN at moderate levels causes impaired balance involving morphological impairments of the vestibule with enhanced levels of oxidative stress. Thus, the results of this study indicate the importance of considering the risk of chronic exposure to LFN at a moderate level for imbalance. Public Library of Science 2012-06-29 /pmc/articles/PMC3387207/ /pubmed/22768129 http://dx.doi.org/10.1371/journal.pone.0039807 Text en Tamura et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Tamura, Haruka
Ohgami, Nobutaka
Yajima, Ichiro
Iida, Machiko
Ohgami, Kyoko
Fujii, Noriko
Itabe, Hiroyuki
Kusudo, Tastuya
Yamashita, Hitoshi
Kato, Masashi
Chronic Exposure to Low Frequency Noise at Moderate Levels Causes Impaired Balance in Mice
title Chronic Exposure to Low Frequency Noise at Moderate Levels Causes Impaired Balance in Mice
title_full Chronic Exposure to Low Frequency Noise at Moderate Levels Causes Impaired Balance in Mice
title_fullStr Chronic Exposure to Low Frequency Noise at Moderate Levels Causes Impaired Balance in Mice
title_full_unstemmed Chronic Exposure to Low Frequency Noise at Moderate Levels Causes Impaired Balance in Mice
title_short Chronic Exposure to Low Frequency Noise at Moderate Levels Causes Impaired Balance in Mice
title_sort chronic exposure to low frequency noise at moderate levels causes impaired balance in mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387207/
https://www.ncbi.nlm.nih.gov/pubmed/22768129
http://dx.doi.org/10.1371/journal.pone.0039807
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