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Biomarker-Based HIV Incidence in a Community Sample of Men Who Have Sex with Men in Paris, France
BACKGROUND: Population-based estimates of HIV incidence in France have revealed that men who have sex with men (MSM) are the most affected population and contribute to nearly half of new infections each year. We sought to estimate HIV incidence among sexually active MSM in Paris gay community social...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387238/ https://www.ncbi.nlm.nih.gov/pubmed/22768150 http://dx.doi.org/10.1371/journal.pone.0039872 |
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author | Le Vu, Stéphane Velter, Annie Meyer, Laurence Peytavin, Gilles Guinard, Jérôme Pillonel, Josiane Barin, Francis Semaille, Caroline |
author_facet | Le Vu, Stéphane Velter, Annie Meyer, Laurence Peytavin, Gilles Guinard, Jérôme Pillonel, Josiane Barin, Francis Semaille, Caroline |
author_sort | Le Vu, Stéphane |
collection | PubMed |
description | BACKGROUND: Population-based estimates of HIV incidence in France have revealed that men who have sex with men (MSM) are the most affected population and contribute to nearly half of new infections each year. We sought to estimate HIV incidence among sexually active MSM in Paris gay community social venues. METHODOLOGY/ PRINCIPAL FINDINGS: A cross-sectional survey was conducted in 2009 in a sample of commercial venues such as bars, saunas and backrooms. We collected a behavioural questionnaire and blood sample. Specimens were tested for HIV infection and positive specimens then tested for recent infection by the enzyme immunoassay for recent HIV-1 infection (EIA-RI). We assessed the presence of antiretroviral therapy among infected individuals to rule out treated patients in the algorithm that determined recent infection. Biomarker-based cross-sectional incidence estimates were calculated. We enrolled 886 MSM participants among which 157 (18%) tested HIV positive. In positive individuals who knew they were infected, 75% of EIA-RI positive results were due to ART. Of 157 HIV positive specimens, 15 were deemed to be recently infected. The overall HIV incidence was estimated at 3.8% person-years(py) [95%CI: 1.5–6.2]. Although differences were not significant, incidence was estimated to be 3.5% py [0.1–6.1] in men having had a negative HIV test in previous year and 4.8% py [0.1–10.6] in men having had their last HIV test more than one year before the survey, or never tested. Incidence was estimated at 4.1% py [0–8.3] in men under 35 years and 2.5% py [0–5.4] in older men. CONCLUSIONS/ SIGNIFICANCE: This is the first community-based survey to estimate HIV incidence among MSM in France. It includes ART detection and reveals a high level of HIV transmission in sexually active individuals, despite a high uptake of HIV testing. These data call for effective prevention programs targeting MSM engaged in high-risk behaviours. |
format | Online Article Text |
id | pubmed-3387238 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-33872382012-07-05 Biomarker-Based HIV Incidence in a Community Sample of Men Who Have Sex with Men in Paris, France Le Vu, Stéphane Velter, Annie Meyer, Laurence Peytavin, Gilles Guinard, Jérôme Pillonel, Josiane Barin, Francis Semaille, Caroline PLoS One Research Article BACKGROUND: Population-based estimates of HIV incidence in France have revealed that men who have sex with men (MSM) are the most affected population and contribute to nearly half of new infections each year. We sought to estimate HIV incidence among sexually active MSM in Paris gay community social venues. METHODOLOGY/ PRINCIPAL FINDINGS: A cross-sectional survey was conducted in 2009 in a sample of commercial venues such as bars, saunas and backrooms. We collected a behavioural questionnaire and blood sample. Specimens were tested for HIV infection and positive specimens then tested for recent infection by the enzyme immunoassay for recent HIV-1 infection (EIA-RI). We assessed the presence of antiretroviral therapy among infected individuals to rule out treated patients in the algorithm that determined recent infection. Biomarker-based cross-sectional incidence estimates were calculated. We enrolled 886 MSM participants among which 157 (18%) tested HIV positive. In positive individuals who knew they were infected, 75% of EIA-RI positive results were due to ART. Of 157 HIV positive specimens, 15 were deemed to be recently infected. The overall HIV incidence was estimated at 3.8% person-years(py) [95%CI: 1.5–6.2]. Although differences were not significant, incidence was estimated to be 3.5% py [0.1–6.1] in men having had a negative HIV test in previous year and 4.8% py [0.1–10.6] in men having had their last HIV test more than one year before the survey, or never tested. Incidence was estimated at 4.1% py [0–8.3] in men under 35 years and 2.5% py [0–5.4] in older men. CONCLUSIONS/ SIGNIFICANCE: This is the first community-based survey to estimate HIV incidence among MSM in France. It includes ART detection and reveals a high level of HIV transmission in sexually active individuals, despite a high uptake of HIV testing. These data call for effective prevention programs targeting MSM engaged in high-risk behaviours. Public Library of Science 2012-06-29 /pmc/articles/PMC3387238/ /pubmed/22768150 http://dx.doi.org/10.1371/journal.pone.0039872 Text en Le Vu et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Le Vu, Stéphane Velter, Annie Meyer, Laurence Peytavin, Gilles Guinard, Jérôme Pillonel, Josiane Barin, Francis Semaille, Caroline Biomarker-Based HIV Incidence in a Community Sample of Men Who Have Sex with Men in Paris, France |
title | Biomarker-Based HIV Incidence in a Community Sample of Men Who Have Sex with Men in Paris, France |
title_full | Biomarker-Based HIV Incidence in a Community Sample of Men Who Have Sex with Men in Paris, France |
title_fullStr | Biomarker-Based HIV Incidence in a Community Sample of Men Who Have Sex with Men in Paris, France |
title_full_unstemmed | Biomarker-Based HIV Incidence in a Community Sample of Men Who Have Sex with Men in Paris, France |
title_short | Biomarker-Based HIV Incidence in a Community Sample of Men Who Have Sex with Men in Paris, France |
title_sort | biomarker-based hiv incidence in a community sample of men who have sex with men in paris, france |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387238/ https://www.ncbi.nlm.nih.gov/pubmed/22768150 http://dx.doi.org/10.1371/journal.pone.0039872 |
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