NOTCH1 Signaling Promotes Human T-Cell Acute Lymphoblastic Leukemia Initiating Cell Regeneration in Supportive Niches

BACKGROUND: Leukemia initiating cells (LIC) contribute to therapeutic resistance through acquisition of mutations in signaling pathways, such as NOTCH1, that promote self-renewal and survival within supportive niches. Activating mutations in NOTCH1 occur commonly in T cell acute lymphoblastic leukem...

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Detalles Bibliográficos
Autores principales: Ma, Wenxue, Gutierrez, Alejandro, Goff, Daniel J., Geron, Ifat, Sadarangani, Anil, Jamieson, Christina A. M., Court, Angela C., Shih, Alice Y., Jiang, Qingfei, Wu, Christina C., Li, Kang, Smith, Kristen M., Crews, Leslie A., Gibson, Neil W., Deichaite, Ida, Morris, Sheldon R., Wei, Ping, Carson, Dennis A., Look, A. Thomas, Jamieson, Catriona H. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387267/
https://www.ncbi.nlm.nih.gov/pubmed/22768113
http://dx.doi.org/10.1371/journal.pone.0039725

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