Cargando…

Deletion of the Scl +19 enhancer increases the blood stem cell compartment without affecting the formation of mature blood lineages

The stem cell leukemia (Scl)/Tal1 gene is essential for normal blood and endothelial development, and is expressed in hematopoietic stem cells (HSCs), progenitors, erythroid, megakaryocytic, and mast cells. The Scl +19 enhancer is active in HSCs and progenitor cells, megakaryocytes, and mast cells,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Spensberger, Dominik, Kotsopoulou, Ekaterini, Ferreira, Rita, Broccardo, Cyril, Scott, Linda M., Fourouclas, Nasios, Ottersbach, Katrin, Green, Anthony R., Göttgens, Berthold
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Science Inc 2012
Materias:	Stem Cells
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387379/ https://www.ncbi.nlm.nih.gov/pubmed/22401818 http://dx.doi.org/10.1016/j.exphem.2012.02.006

Ejemplares similares

p57Kip2 regulates embryonic blood stem cells by controlling sympathoadrenal progenitor expansion
por: Kapeni, Chrysa, et al.
Publicado: (2022)

Mapping and Functional Characterisation of a CTCF-Dependent Insulator Element at the 3′ Border of the Murine Scl Transcriptional Domain
por: Follows, George A., et al.
Publicado: (2012)

Single-cell transcriptome analysis of CAR T-cell products reveals subpopulations, stimulation, and exhaustion signatures
por: Wang, Xiaonan, et al.
Publicado: (2021)

Pattern of tamoxifen-induced Tie2 deletion in endothelial cells in mature blood vessels using endo SCL-Cre-ERT transgenic mice
por: Zwiers, Peter J., et al.
Publicado: (2022)

SCL/TAL1 cooperates with Polycomb RYBP-PRC1 to suppress alternative lineages in blood-fated cells
por: Chagraoui, Hedia, et al.
Publicado: (2018)

Combining single-cell tracking and omics improves blood stem cell fate regulator identification
por: Wehling, A., et al.
Publicado: (2022)

Genome-wide Analysis of Simultaneous GATA1/2, RUNX1, FLI1, and SCL Binding in Megakaryocytes Identifies Hematopoietic Regulators
por: Tijssen, Marloes R., et al.
Publicado: (2011)

Activation of KLF1 Enhances the Differentiation and Maturation of Red Blood Cells from Human Pluripotent Stem Cells
por: Yang, Cheng‐Tao, et al.
Publicado: (2017)

A HaemAtlas: characterizing gene expression in differentiated human blood cells
por: Watkins, Nicholas A., et al.
Publicado: (2009)

Enforced Expression of HOXB4 in Human Embryonic Stem Cells Enhances the Production of Hematopoietic Progenitors but Has No Effect on the Maturation of Red Blood Cells
por: Jackson, Melany, et al.
Publicado: (2016)

Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation
por: Kerenyi, Marc A, et al.
Publicado: (2013)

Lgr5(+) stem and progenitor cells reside at the apex of a heterogeneous embryonic hepatoblast pool
por: Prior, Nicole, et al.
Publicado: (2019)

Developmental compartments in the larval trachea of Drosophila
por: Rao, Prashanth R, et al.
Publicado: (2015)

Runx1 promotes scar deposition and inhibits myocardial proliferation and survival during zebrafish heart regeneration
por: Koth, Jana, et al.
Publicado: (2020)

Brg1 modulates enhancer activation in mesoderm lineage commitment
por: Alexander, Jeffrey M., et al.
Publicado: (2015)

Concerted bioinformatic analysis of the genome-scale blood transcription factor compendium reveals new control mechanisms
por: Joshi, Anagha, et al.
Publicado: (2014)

Energy upgrade of the EHF SCL
por: Vretenar, Maurizio, et al.
Publicado: (1987)

SCL chips in for Big Bang
por: Singh Nibber, Gurpreet
Publicado: (2005)

BMP4 triggers regulatory circuits specifying the cardiac mesoderm lineage
por: Tsaytler, Pavel, et al.
Publicado: (2023)

Endothelial-to-haematopoietic transition: an update on the process of making blood
por: Ottersbach, Katrin
Publicado: (2019)

Hyaluronan Is Crucial for Stem Cell Differentiation into Smooth Muscle Lineage
por: Simpson, Russell M.L., et al.
Publicado: (2016)

Transgressions of compartment boundaries and cell reprogramming during regeneration in Drosophila
por: Herrera, Salvador C, et al.
Publicado: (2014)

Myelo-lymphoid lineage restriction occurs in the human haematopoietic stem cell compartment before lymphoid-primed multipotent progenitors
por: Belluschi, Serena, et al.
Publicado: (2018)

Defining the three cell lineages of the human blastocyst by single-cell RNA-seq
por: Blakeley, Paul, et al.
Publicado: (2015)

Neutral lineage tracing of proliferative embryonic and adult mammary stem/progenitor cells
por: Lloyd-Lewis, Bethan, et al.
Publicado: (2018)

Aldh2 is a lineage-specific metabolic gatekeeper in melanocyte stem cells
por: Brunsdon, Hannah, et al.
Publicado: (2022)

Neuronatin Promotes Neural Lineage in ESCs via Ca(2+) Signaling
por: Lin, Hsuan-Hwai, et al.
Publicado: (2010)

The Epidermis Comprises Autonomous Compartments Maintained by Distinct Stem Cell Populations
por: Page, Mahalia E., et al.
Publicado: (2013)

p53 activity is selectively licensed in the Drosophila stem cell compartment
por: Wylie, Annika, et al.
Publicado: (2014)

Oct4 is required for lineage priming in the developing inner cell mass of the mouse blastocyst
por: Le Bin, Gloryn Chia, et al.
Publicado: (2014)

Constraint of gene expression by the chromatin remodelling protein CHD4 facilitates lineage specification
por: O'Shaughnessy-Kirwan, Aoife, et al.
Publicado: (2015)

The BAF chromatin remodelling complex is an epigenetic regulator of lineage specification in the early mouse embryo
por: Panamarova, Maryna, et al.
Publicado: (2016)

Distinct Wnt-driven primitive streak-like populations reflect in vivo lineage precursors
por: Tsakiridis, Anestis, et al.
Publicado: (2014)

Regulation of RUNX1 dosage is crucial for efficient blood formation from hemogenic endothelium
por: Lie-A-Ling, Michael, et al.
Publicado: (2018)

The lasting influence of LSD1 in the blood
por: Dent, Sharon YR, et al.
Publicado: (2013)

The myeloid lineage is required for the emergence of a regeneration-permissive environment following Xenopus tail amputation
por: Aztekin, Can, et al.
Publicado: (2020)

Hypoxia induces an early primitive streak signature, enhancing spontaneous elongation and lineage representation in gastruloids
por: López-Anguita, Natalia, et al.
Publicado: (2022)

Elevated glucosylsphingosine in Gaucher disease induced pluripotent stem cell neurons deregulates lysosomal compartment through mammalian target of rapamycin complex 1
por: Srikanth, Manasa P., et al.
Publicado: (2021)

Novel population of human monocyte and osteoclast progenitors from pluripotent stem cells and peripheral blood
por: Root, Sierra H., et al.
Publicado: (2021)

Genome-wide whole-blood transcriptome profiling across inherited bone marrow failure subtypes
por: Walne, Amanda J., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ci85hm6gs5bo1p5n6lppoki94l