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Statin pre-treatment is associated with lower platelet activity and favorable outcome in patients with acute non-cardio-embolic ischemic stroke

INTRODUCTION: Statins reportedly have anti-inflammatory and anti-thrombotic effects aside from cholesterol-lowering. This study aimed to evaluate the effect of pre-existing statin use on platelet activation markers and clinical outcome in acute ischemic stroke patients. METHODS: This prospective stu...

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Autores principales: Tsai, Nai-Wen, Lin, Tsu-Kung, Chang, Wen-Neng, Jan, Chung-Ren, Huang, Chi-Ren, Chen, Shang-Der, Cheng, Kuei-Yueh, Chiang, Yi-Fang, Wang, Hung-Chen, Yang, Tzu-Ming, Lin, Yu-Jun, Lin, Wei-Che, Chang, Hsueh-Wen, Lee, Lian-Hui, Lu, Cheng-Hsien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387600/
https://www.ncbi.nlm.nih.gov/pubmed/21740551
http://dx.doi.org/10.1186/cc10303
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author Tsai, Nai-Wen
Lin, Tsu-Kung
Chang, Wen-Neng
Jan, Chung-Ren
Huang, Chi-Ren
Chen, Shang-Der
Cheng, Kuei-Yueh
Chiang, Yi-Fang
Wang, Hung-Chen
Yang, Tzu-Ming
Lin, Yu-Jun
Lin, Wei-Che
Chang, Hsueh-Wen
Lee, Lian-Hui
Lu, Cheng-Hsien
author_facet Tsai, Nai-Wen
Lin, Tsu-Kung
Chang, Wen-Neng
Jan, Chung-Ren
Huang, Chi-Ren
Chen, Shang-Der
Cheng, Kuei-Yueh
Chiang, Yi-Fang
Wang, Hung-Chen
Yang, Tzu-Ming
Lin, Yu-Jun
Lin, Wei-Che
Chang, Hsueh-Wen
Lee, Lian-Hui
Lu, Cheng-Hsien
author_sort Tsai, Nai-Wen
collection PubMed
description INTRODUCTION: Statins reportedly have anti-inflammatory and anti-thrombotic effects aside from cholesterol-lowering. This study aimed to evaluate the effect of pre-existing statin use on platelet activation markers and clinical outcome in acute ischemic stroke patients. METHODS: This prospective study evaluated 172 patients with acute ischemic stroke divided in two groups: patients with pre-existing statin (n = 43) and without pre-existing statin (66 cases with statins initiated post-stroke and 63 without statin treatment). Platelet activation markers (CD62P and CD63) were measured by flow cytometry at different time points after stroke and analyzed with clinical outcome. RESULTS: The CD62P and CD63 expressions on platelets were significantly lower in the patients with pre-existing statin use compared to the patients without pre-existing statin use on Day 1 post-stroke (p < 0.05). The CD62P expression was significantly lower in the patients with pre-existing statin use on 90 days after the acute stroke (p < 0.05). Patients with pre-existing statin use had lower incidences of early neurologic deterioration (END) than those without treatment (p < 0.05). Among several baseline clinical variables, admission NIHSS score, history of coronary artery disease, and pre-existing statin use were independent predictions of good clinical outcome at three months. CONCLUSIONS: Pre-existing statin use is associated with decreased platelet activity as well as improved clinical outcome and reduced END in patients with acute ischemic stroke.
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spelling pubmed-33876002012-07-02 Statin pre-treatment is associated with lower platelet activity and favorable outcome in patients with acute non-cardio-embolic ischemic stroke Tsai, Nai-Wen Lin, Tsu-Kung Chang, Wen-Neng Jan, Chung-Ren Huang, Chi-Ren Chen, Shang-Der Cheng, Kuei-Yueh Chiang, Yi-Fang Wang, Hung-Chen Yang, Tzu-Ming Lin, Yu-Jun Lin, Wei-Che Chang, Hsueh-Wen Lee, Lian-Hui Lu, Cheng-Hsien Crit Care Research INTRODUCTION: Statins reportedly have anti-inflammatory and anti-thrombotic effects aside from cholesterol-lowering. This study aimed to evaluate the effect of pre-existing statin use on platelet activation markers and clinical outcome in acute ischemic stroke patients. METHODS: This prospective study evaluated 172 patients with acute ischemic stroke divided in two groups: patients with pre-existing statin (n = 43) and without pre-existing statin (66 cases with statins initiated post-stroke and 63 without statin treatment). Platelet activation markers (CD62P and CD63) were measured by flow cytometry at different time points after stroke and analyzed with clinical outcome. RESULTS: The CD62P and CD63 expressions on platelets were significantly lower in the patients with pre-existing statin use compared to the patients without pre-existing statin use on Day 1 post-stroke (p < 0.05). The CD62P expression was significantly lower in the patients with pre-existing statin use on 90 days after the acute stroke (p < 0.05). Patients with pre-existing statin use had lower incidences of early neurologic deterioration (END) than those without treatment (p < 0.05). Among several baseline clinical variables, admission NIHSS score, history of coronary artery disease, and pre-existing statin use were independent predictions of good clinical outcome at three months. CONCLUSIONS: Pre-existing statin use is associated with decreased platelet activity as well as improved clinical outcome and reduced END in patients with acute ischemic stroke. BioMed Central 2011 2011-07-08 /pmc/articles/PMC3387600/ /pubmed/21740551 http://dx.doi.org/10.1186/cc10303 Text en Copyright ©2011 Tsai et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Tsai, Nai-Wen
Lin, Tsu-Kung
Chang, Wen-Neng
Jan, Chung-Ren
Huang, Chi-Ren
Chen, Shang-Der
Cheng, Kuei-Yueh
Chiang, Yi-Fang
Wang, Hung-Chen
Yang, Tzu-Ming
Lin, Yu-Jun
Lin, Wei-Che
Chang, Hsueh-Wen
Lee, Lian-Hui
Lu, Cheng-Hsien
Statin pre-treatment is associated with lower platelet activity and favorable outcome in patients with acute non-cardio-embolic ischemic stroke
title Statin pre-treatment is associated with lower platelet activity and favorable outcome in patients with acute non-cardio-embolic ischemic stroke
title_full Statin pre-treatment is associated with lower platelet activity and favorable outcome in patients with acute non-cardio-embolic ischemic stroke
title_fullStr Statin pre-treatment is associated with lower platelet activity and favorable outcome in patients with acute non-cardio-embolic ischemic stroke
title_full_unstemmed Statin pre-treatment is associated with lower platelet activity and favorable outcome in patients with acute non-cardio-embolic ischemic stroke
title_short Statin pre-treatment is associated with lower platelet activity and favorable outcome in patients with acute non-cardio-embolic ischemic stroke
title_sort statin pre-treatment is associated with lower platelet activity and favorable outcome in patients with acute non-cardio-embolic ischemic stroke
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387600/
https://www.ncbi.nlm.nih.gov/pubmed/21740551
http://dx.doi.org/10.1186/cc10303
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