SULT1A1 rs9282861 polymorphism-a potential modifier of efficacy of the systemic adjuvant therapy in breast cancer?

BACKGROUND: Sulfotransferase 1A1 (SULT1A1) participates in the elimination of 4-hydroxy-tamoxifen (4-OH-TAM), which is one of the major active metabolites of tamoxifen (TAM). Homozygous SULT1A1 variant allele genotype has been associated with lower catalytic activity and thermostability of the enzym...

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Detalles Bibliográficos
Autores principales: Tengström, Maria, Mannermaa, Arto, Kosma, Veli-Matti, Hirvonen, Ari, Kataja, Vesa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388009/
https://www.ncbi.nlm.nih.gov/pubmed/22708928
http://dx.doi.org/10.1186/1471-2407-12-257

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