Cargando…

Association between XPF Polymorphisms and Cancer Risk: A Meta-Analysis

BACKGROUND: Xeroderma pigmentosum complementation group F (XPF or ERCC4) plays a key role in DNA repair that protects against genetic instability and carcinogenesis. A series of epidemiological studies have examined associations between XPF polymorphisms and cancer risk, but the findings remain inco...

Descripción completa

Detalles Bibliográficos
Autores principales: Shi, Ting-Yan, He, Jing, Qiu, Li-Xin, Zhu, Mei-Ling, Wang, Meng-Yun, Zhou, Xiao-Yan, Han, Jiali, Yu, Hongpin, Zang, Rong-Yu, Wei, Qingyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388076/
https://www.ncbi.nlm.nih.gov/pubmed/22768293
http://dx.doi.org/10.1371/journal.pone.0038606
_version_ 1782237141706735616
author Shi, Ting-Yan
He, Jing
Qiu, Li-Xin
Zhu, Mei-Ling
Wang, Meng-Yun
Zhou, Xiao-Yan
Han, Jiali
Yu, Hongpin
Zang, Rong-Yu
Wei, Qingyi
author_facet Shi, Ting-Yan
He, Jing
Qiu, Li-Xin
Zhu, Mei-Ling
Wang, Meng-Yun
Zhou, Xiao-Yan
Han, Jiali
Yu, Hongpin
Zang, Rong-Yu
Wei, Qingyi
author_sort Shi, Ting-Yan
collection PubMed
description BACKGROUND: Xeroderma pigmentosum complementation group F (XPF or ERCC4) plays a key role in DNA repair that protects against genetic instability and carcinogenesis. A series of epidemiological studies have examined associations between XPF polymorphisms and cancer risk, but the findings remain inconclusive. METHODOLOGY/PRINCIPAL FINDINGS: In this meta-analysis of 47,639 cancer cases and 51,915 controls, by searching three electronic databases (i.e., MEDLINE, EMBASE and CNKI), we summarized 43 case-control studies from 29 publications on four commonly studied polymorphisms of XPF (i.e., rs1800067, rs1799801, rs2020955 and rs744154), and we did not find statistical evidence of any significant association with overall cancer risk. However, in stratification analyses, we found a significant association of XPF-rs1799801 with a reduced cancer risk in Caucasian populations (4,845 cases and 5,556 controls; recessive model: OR = 0.87, 95% CI = 0.76–1.00, P = 0.049, P = 0.723 for heterogeneity test, I(2) = 0). Further genotype-phenotype correlation analysis showed that the homozygous variant CC genotype carriers had higher XPF expression levels than that of the TT genotype carriers (Student’s t test for a recessive model: P = 0.046). No publication bias was found by using the funnel plot and Egger’s test. CONCLUSION: This meta-analysis suggests a lack of statistical evidence for the association between the four XPF SNPs and overall risk of cancers. However, XPF-rs1799801 may be associated with cancer risk in Caucasian populations, which needs to be further validated in single large, well-designed prospective studies.
format Online
Article
Text
id pubmed-3388076
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-33880762012-07-05 Association between XPF Polymorphisms and Cancer Risk: A Meta-Analysis Shi, Ting-Yan He, Jing Qiu, Li-Xin Zhu, Mei-Ling Wang, Meng-Yun Zhou, Xiao-Yan Han, Jiali Yu, Hongpin Zang, Rong-Yu Wei, Qingyi PLoS One Research Article BACKGROUND: Xeroderma pigmentosum complementation group F (XPF or ERCC4) plays a key role in DNA repair that protects against genetic instability and carcinogenesis. A series of epidemiological studies have examined associations between XPF polymorphisms and cancer risk, but the findings remain inconclusive. METHODOLOGY/PRINCIPAL FINDINGS: In this meta-analysis of 47,639 cancer cases and 51,915 controls, by searching three electronic databases (i.e., MEDLINE, EMBASE and CNKI), we summarized 43 case-control studies from 29 publications on four commonly studied polymorphisms of XPF (i.e., rs1800067, rs1799801, rs2020955 and rs744154), and we did not find statistical evidence of any significant association with overall cancer risk. However, in stratification analyses, we found a significant association of XPF-rs1799801 with a reduced cancer risk in Caucasian populations (4,845 cases and 5,556 controls; recessive model: OR = 0.87, 95% CI = 0.76–1.00, P = 0.049, P = 0.723 for heterogeneity test, I(2) = 0). Further genotype-phenotype correlation analysis showed that the homozygous variant CC genotype carriers had higher XPF expression levels than that of the TT genotype carriers (Student’s t test for a recessive model: P = 0.046). No publication bias was found by using the funnel plot and Egger’s test. CONCLUSION: This meta-analysis suggests a lack of statistical evidence for the association between the four XPF SNPs and overall risk of cancers. However, XPF-rs1799801 may be associated with cancer risk in Caucasian populations, which needs to be further validated in single large, well-designed prospective studies. Public Library of Science 2012-07-02 /pmc/articles/PMC3388076/ /pubmed/22768293 http://dx.doi.org/10.1371/journal.pone.0038606 Text en Shi et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Shi, Ting-Yan
He, Jing
Qiu, Li-Xin
Zhu, Mei-Ling
Wang, Meng-Yun
Zhou, Xiao-Yan
Han, Jiali
Yu, Hongpin
Zang, Rong-Yu
Wei, Qingyi
Association between XPF Polymorphisms and Cancer Risk: A Meta-Analysis
title Association between XPF Polymorphisms and Cancer Risk: A Meta-Analysis
title_full Association between XPF Polymorphisms and Cancer Risk: A Meta-Analysis
title_fullStr Association between XPF Polymorphisms and Cancer Risk: A Meta-Analysis
title_full_unstemmed Association between XPF Polymorphisms and Cancer Risk: A Meta-Analysis
title_short Association between XPF Polymorphisms and Cancer Risk: A Meta-Analysis
title_sort association between xpf polymorphisms and cancer risk: a meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388076/
https://www.ncbi.nlm.nih.gov/pubmed/22768293
http://dx.doi.org/10.1371/journal.pone.0038606
work_keys_str_mv AT shitingyan associationbetweenxpfpolymorphismsandcancerriskametaanalysis
AT hejing associationbetweenxpfpolymorphismsandcancerriskametaanalysis
AT qiulixin associationbetweenxpfpolymorphismsandcancerriskametaanalysis
AT zhumeiling associationbetweenxpfpolymorphismsandcancerriskametaanalysis
AT wangmengyun associationbetweenxpfpolymorphismsandcancerriskametaanalysis
AT zhouxiaoyan associationbetweenxpfpolymorphismsandcancerriskametaanalysis
AT hanjiali associationbetweenxpfpolymorphismsandcancerriskametaanalysis
AT yuhongpin associationbetweenxpfpolymorphismsandcancerriskametaanalysis
AT zangrongyu associationbetweenxpfpolymorphismsandcancerriskametaanalysis
AT weiqingyi associationbetweenxpfpolymorphismsandcancerriskametaanalysis