Single Nucleotide Polymorphism (SNP)-Based Loss of Heterozygosity (LOH) Testing by Real Time PCR in Patients Suspect of Myeloproliferative Disease

During tumor development, loss of heterozygosity (LOH) often occurs. When LOH is preceded by an oncogene activating mutation, the mutant allele may be further potentiated if the wild-type allele is lost or inactivated. In myeloproliferative neoplasms (MPN) somatic acquisition of JAK2V617F may be fol...

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Detalles Bibliográficos
Autores principales: Huijsmans, Cornelis J. J., Poodt, Jeroen, Damen, Jan, van der Linden, Johannes C., Savelkoul, Paul H. M., Pruijt, Johannes F. M., Hilbink, Mirrian, Hermans, Mirjam H. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388082/
https://www.ncbi.nlm.nih.gov/pubmed/22768290
http://dx.doi.org/10.1371/journal.pone.0038362

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