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Fluorophore Labeled Kinase Detects Ligands That Bind within the MAPK Insert of p38α Kinase
The vast majority of small molecules known to modulate kinase activity, target the highly conserved ATP-pocket. Consequently, such ligands are often less specific and in case of inhibitors, this leads to the inhibition of multiple kinases. Thus, selective modulation of kinase function remains a majo...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388095/ https://www.ncbi.nlm.nih.gov/pubmed/22768308 http://dx.doi.org/10.1371/journal.pone.0039713 |