A chemical screen identifies the chemotherapeutic drug topotecan as a specific inhibitor of the B-MYB/MYCN axis in neuroblastoma

The transcription factor MycN is the prototypical neuroblastoma oncogene and a potential therapeutic target. However, its strong expression caused by gene amplification in about 30% of neuroblastoma patients is a considerable obstacle to the development of therapeutic approaches aiming at eliminatin...

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Detalles Bibliográficos
Autores principales: Sottile, Francesco, Gnemmi, Ilaria, Cantilena, Sandra, D'Acunto, Walter C., Sala, Arturo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2012
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388183/
https://www.ncbi.nlm.nih.gov/pubmed/22619121

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