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Coordination between proteasome impairment and caspase activation leading to TAU pathology: neuroprotection by cAMP

Neurofibrillary tangles (NFTs) are hallmarks of Alzheimer's disease (AD). The main component of NFTs is TAU, a highly soluble microtubule-associated protein. However, when TAU is cleaved at Asp421 by caspases it becomes prone to aggregation leading to NFTs. What triggers caspase activation resu...

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Detalles Bibliográficos
Autores principales:	Metcalfe, M J, Huang, Q, Figueiredo-Pereira, M E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2012
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388240/ https://www.ncbi.nlm.nih.gov/pubmed/22717581 http://dx.doi.org/10.1038/cddis.2012.70

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