Perk-dependent repression of miR-106b-25 cluster is required for ER stress-induced apoptosis

Activation of the unfolded protein response sensor PKR-like endoplasmic reticulum kinase (Perk) attenuates endoplasmic reticulum (ER) stress levels. Conversantly, if the damage is too severe and ER function cannot be restored, this signaling branch triggers apoptosis. Bcl-2 homology 3-only family me...

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Detalles Bibliográficos
Autores principales: Gupta, S, Read, D E, Deepti, A, Cawley, K, Gupta, A, Oommen, D, Verfaillie, T, Matus, S, Smith, M A, Mott, J L, Agostinis, P, Hetz, C, Samali, A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388242/
https://www.ncbi.nlm.nih.gov/pubmed/22739985
http://dx.doi.org/10.1038/cddis.2012.74

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