HtrA2 deficiency causes mitochondrial uncoupling through the F(1)F(0)-ATP synthase and consequent ATP depletion

Loss of the mitochondrial protease HtrA2 (Omi) in mice leads to mitochondrial dysfunction, neurodegeneration and premature death, but the mechanism underlying this pathology remains unclear. Using primary cultures from wild-type and HtrA2-knockout mice, we find that HtrA2 deficiency significantly re...

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Detalles Bibliográficos
Autores principales: Plun-Favreau, H, Burchell, V S, Holmström, K M, Yao, Z, Deas, E, Cain, K, Fedele, V, Moisoi, N, Campanella, M, Miguel Martins, L, Wood, N W, Gourine, A V, Abramov, A Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388244/
https://www.ncbi.nlm.nih.gov/pubmed/22739987
http://dx.doi.org/10.1038/cddis.2012.77

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