BRCA1 negatively regulates IGF-1 expression through an estrogen-responsive element-like site

The insulin-like growth factor-1 receptor (IGF-1R) signaling pathway is critical for both normal mammary gland development and malignant transformation. It has been reported that the IGF-1 stimulates breast cancer cell proliferation and is upregulated in tumors with BRCA1/2 mutations. We report here...

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Detalles Bibliográficos
Autores principales: Kang, H J, Yi, Y W, Kim, H J, Hong, Y B, Seong, Y S, Bae, I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388245/
https://www.ncbi.nlm.nih.gov/pubmed/22739988
http://dx.doi.org/10.1038/cddis.2012.78

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388245/
https://www.ncbi.nlm.nih.gov/pubmed/22739988
http://dx.doi.org/10.1038/cddis.2012.78

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