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Thymidine Kinase 1 Upregulation Is an Early Event in Breast Tumor Formation

Prognostic markers play an important role in our understanding of tumors and how to treat them. Thymidine kinase 1 (TK1), a proliferation marker involved in DNA repair, has been shown to have independent prognostic potential. This prognostic potential includes the novel concept that upregulation of...

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Detalles Bibliográficos
Autores principales: Alegre, Melissa M., Robison, Richard A., O'Neill, Kim L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388419/
https://www.ncbi.nlm.nih.gov/pubmed/22778736
http://dx.doi.org/10.1155/2012/575647
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author Alegre, Melissa M.
Robison, Richard A.
O'Neill, Kim L.
author_facet Alegre, Melissa M.
Robison, Richard A.
O'Neill, Kim L.
author_sort Alegre, Melissa M.
collection PubMed
description Prognostic markers play an important role in our understanding of tumors and how to treat them. Thymidine kinase 1 (TK1), a proliferation marker involved in DNA repair, has been shown to have independent prognostic potential. This prognostic potential includes the novel concept that upregulation of serum TK1 levels is an early event in cancer development. This same effect may also be seen in tumor tissue. In order to demonstrate that TK1 upregulation is an early event in tumor tissue formation, tissue arrays were obtained and stained for TK1 by immunohistochemistry. Using a progressive breast tissue array, precancerous tissue including breast adenosis, simple hyperplasia, and atypical hyperplasia stained positive for TK1 expression. Different stages of breast carcinoma tissue also stained positive for TK1 including nonspecific infiltrating duct, infiltrating lobular, and infiltrating duct with lymph node metastasis carcinomas. This indicates that TK1 upregulation is an early event in breast carcinoma development, and may be useful in identifying precancerous tissue. Further work is needed to better understand the differences seen between TK1 positive and negative tissues.
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spelling pubmed-33884192012-07-09 Thymidine Kinase 1 Upregulation Is an Early Event in Breast Tumor Formation Alegre, Melissa M. Robison, Richard A. O'Neill, Kim L. J Oncol Research Article Prognostic markers play an important role in our understanding of tumors and how to treat them. Thymidine kinase 1 (TK1), a proliferation marker involved in DNA repair, has been shown to have independent prognostic potential. This prognostic potential includes the novel concept that upregulation of serum TK1 levels is an early event in cancer development. This same effect may also be seen in tumor tissue. In order to demonstrate that TK1 upregulation is an early event in tumor tissue formation, tissue arrays were obtained and stained for TK1 by immunohistochemistry. Using a progressive breast tissue array, precancerous tissue including breast adenosis, simple hyperplasia, and atypical hyperplasia stained positive for TK1 expression. Different stages of breast carcinoma tissue also stained positive for TK1 including nonspecific infiltrating duct, infiltrating lobular, and infiltrating duct with lymph node metastasis carcinomas. This indicates that TK1 upregulation is an early event in breast carcinoma development, and may be useful in identifying precancerous tissue. Further work is needed to better understand the differences seen between TK1 positive and negative tissues. Hindawi Publishing Corporation 2012 2012-06-19 /pmc/articles/PMC3388419/ /pubmed/22778736 http://dx.doi.org/10.1155/2012/575647 Text en Copyright © 2012 Melissa M. Alegre et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Alegre, Melissa M.
Robison, Richard A.
O'Neill, Kim L.
Thymidine Kinase 1 Upregulation Is an Early Event in Breast Tumor Formation
title Thymidine Kinase 1 Upregulation Is an Early Event in Breast Tumor Formation
title_full Thymidine Kinase 1 Upregulation Is an Early Event in Breast Tumor Formation
title_fullStr Thymidine Kinase 1 Upregulation Is an Early Event in Breast Tumor Formation
title_full_unstemmed Thymidine Kinase 1 Upregulation Is an Early Event in Breast Tumor Formation
title_short Thymidine Kinase 1 Upregulation Is an Early Event in Breast Tumor Formation
title_sort thymidine kinase 1 upregulation is an early event in breast tumor formation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388419/
https://www.ncbi.nlm.nih.gov/pubmed/22778736
http://dx.doi.org/10.1155/2012/575647
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