Cargando…

Zebrafish Thrombocytes: Functions and Origins

Platelets play an important role in mammalian hemostasis. Thrombocytes of early vertebrates are functionally equivalent to mammalian platelets. A substantial amount of research has been done to study platelet function in humans as well as in animal models. However, to date only limited functional ge...

Descripción completa

Detalles Bibliográficos
Autores principales: Khandekar, Gauri, Kim, Seongcheol, Jagadeeswaran, Pudur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388482/
https://www.ncbi.nlm.nih.gov/pubmed/22778746
http://dx.doi.org/10.1155/2012/857058
_version_ 1782237199518924800
author Khandekar, Gauri
Kim, Seongcheol
Jagadeeswaran, Pudur
author_facet Khandekar, Gauri
Kim, Seongcheol
Jagadeeswaran, Pudur
author_sort Khandekar, Gauri
collection PubMed
description Platelets play an important role in mammalian hemostasis. Thrombocytes of early vertebrates are functionally equivalent to mammalian platelets. A substantial amount of research has been done to study platelet function in humans as well as in animal models. However, to date only limited functional genomic studies of platelets have been performed but are low throughput and are not cost-effective. Keeping this in mind we introduced zebrafish, a vertebrate genetic model to study platelet function. We characterized zebrafish thrombocytes and established functional assays study not only their hemostatic function but to also their production. We identified a few genes which play a role in their function and production. Since we introduced the zebrafish model for the study of hemostasis and thrombosis, other groups have adapted this model to study genes that are associated with thrombocyte function and a few novel genes have also been identified. Furthermore, transgenic zebrafish with GFP-tagged thrombocytes have been developed which helped to study the production of thrombocytes and their precursors as well as their functional roles not only in hemostasis but also hematopoiesis. This paper integrates the information available on zebrafish thrombocyte function and its formation.
format Online
Article
Text
id pubmed-3388482
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-33884822012-07-09 Zebrafish Thrombocytes: Functions and Origins Khandekar, Gauri Kim, Seongcheol Jagadeeswaran, Pudur Adv Hematol Review Article Platelets play an important role in mammalian hemostasis. Thrombocytes of early vertebrates are functionally equivalent to mammalian platelets. A substantial amount of research has been done to study platelet function in humans as well as in animal models. However, to date only limited functional genomic studies of platelets have been performed but are low throughput and are not cost-effective. Keeping this in mind we introduced zebrafish, a vertebrate genetic model to study platelet function. We characterized zebrafish thrombocytes and established functional assays study not only their hemostatic function but to also their production. We identified a few genes which play a role in their function and production. Since we introduced the zebrafish model for the study of hemostasis and thrombosis, other groups have adapted this model to study genes that are associated with thrombocyte function and a few novel genes have also been identified. Furthermore, transgenic zebrafish with GFP-tagged thrombocytes have been developed which helped to study the production of thrombocytes and their precursors as well as their functional roles not only in hemostasis but also hematopoiesis. This paper integrates the information available on zebrafish thrombocyte function and its formation. Hindawi Publishing Corporation 2012 2012-06-24 /pmc/articles/PMC3388482/ /pubmed/22778746 http://dx.doi.org/10.1155/2012/857058 Text en Copyright © 2012 Gauri Khandekar et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Khandekar, Gauri
Kim, Seongcheol
Jagadeeswaran, Pudur
Zebrafish Thrombocytes: Functions and Origins
title Zebrafish Thrombocytes: Functions and Origins
title_full Zebrafish Thrombocytes: Functions and Origins
title_fullStr Zebrafish Thrombocytes: Functions and Origins
title_full_unstemmed Zebrafish Thrombocytes: Functions and Origins
title_short Zebrafish Thrombocytes: Functions and Origins
title_sort zebrafish thrombocytes: functions and origins
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388482/
https://www.ncbi.nlm.nih.gov/pubmed/22778746
http://dx.doi.org/10.1155/2012/857058
work_keys_str_mv AT khandekargauri zebrafishthrombocytesfunctionsandorigins
AT kimseongcheol zebrafishthrombocytesfunctionsandorigins
AT jagadeeswaranpudur zebrafishthrombocytesfunctionsandorigins