The role of mesenchymal stem cells in anti-cancer drug resistance and tumour progression

It is becoming increasingly clear that the tumour microenvironment has a very important role in tumour progression and drug resistance. Many different cell types within the tumour stroma have an effect on tumour progression either in a positive or in a negative way. Mesenchymal stem cells (MSCs) are...

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Autores principales: Houthuijzen, J M, Daenen, L G M, Roodhart, J M L, Voest, E E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388567/
https://www.ncbi.nlm.nih.gov/pubmed/22596239
http://dx.doi.org/10.1038/bjc.2012.201
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author Houthuijzen, J M
Daenen, L G M
Roodhart, J M L
Voest, E E
author_facet Houthuijzen, J M
Daenen, L G M
Roodhart, J M L
Voest, E E
author_sort Houthuijzen, J M
collection PubMed
description It is becoming increasingly clear that the tumour microenvironment has a very important role in tumour progression and drug resistance. Many different cell types within the tumour stroma have an effect on tumour progression either in a positive or in a negative way. Mesenchymal stem cells (MSCs) are a distinct population of cells that have been linked with tumour growth. Mesenchymal stem cells can home to tumours where they modulate the immune system and facilitate tumour growth, angiogenesis and metastasis. Recent studies have shown that MSCs also have an important role in the resistance to various anti-cancer drugs. This mini-review provides an overview of the functional properties of MSCs in tumour progression and drug resistance.
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spelling pubmed-33885672013-06-05 The role of mesenchymal stem cells in anti-cancer drug resistance and tumour progression Houthuijzen, J M Daenen, L G M Roodhart, J M L Voest, E E Br J Cancer Minireview It is becoming increasingly clear that the tumour microenvironment has a very important role in tumour progression and drug resistance. Many different cell types within the tumour stroma have an effect on tumour progression either in a positive or in a negative way. Mesenchymal stem cells (MSCs) are a distinct population of cells that have been linked with tumour growth. Mesenchymal stem cells can home to tumours where they modulate the immune system and facilitate tumour growth, angiogenesis and metastasis. Recent studies have shown that MSCs also have an important role in the resistance to various anti-cancer drugs. This mini-review provides an overview of the functional properties of MSCs in tumour progression and drug resistance. Nature Publishing Group 2012-06-05 2012-05-17 /pmc/articles/PMC3388567/ /pubmed/22596239 http://dx.doi.org/10.1038/bjc.2012.201 Text en Copyright © 2012 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Minireview
Houthuijzen, J M
Daenen, L G M
Roodhart, J M L
Voest, E E
The role of mesenchymal stem cells in anti-cancer drug resistance and tumour progression
title The role of mesenchymal stem cells in anti-cancer drug resistance and tumour progression
title_full The role of mesenchymal stem cells in anti-cancer drug resistance and tumour progression
title_fullStr The role of mesenchymal stem cells in anti-cancer drug resistance and tumour progression
title_full_unstemmed The role of mesenchymal stem cells in anti-cancer drug resistance and tumour progression
title_short The role of mesenchymal stem cells in anti-cancer drug resistance and tumour progression
title_sort role of mesenchymal stem cells in anti-cancer drug resistance and tumour progression
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388567/
https://www.ncbi.nlm.nih.gov/pubmed/22596239
http://dx.doi.org/10.1038/bjc.2012.201
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