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The role of mitochondria in yeast programmed cell death

Mammalian apoptosis and yeast programmed cell death (PCD) share a variety of features including reactive oxygen species production, protease activity and a major role played by mitochondria. In view of this, and of the distinctive characteristics differentiating yeast and multicellular organism PCD,...

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Autores principales: Guaragnella, Nicoletta, Ždralević, Maša, Antonacci, Lucia, Passarella, Salvatore, Marra, Ersilia, Giannattasio, Sergio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388595/
https://www.ncbi.nlm.nih.gov/pubmed/22783546
http://dx.doi.org/10.3389/fonc.2012.00070
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author Guaragnella, Nicoletta
Ždralević, Maša
Antonacci, Lucia
Passarella, Salvatore
Marra, Ersilia
Giannattasio, Sergio
author_facet Guaragnella, Nicoletta
Ždralević, Maša
Antonacci, Lucia
Passarella, Salvatore
Marra, Ersilia
Giannattasio, Sergio
author_sort Guaragnella, Nicoletta
collection PubMed
description Mammalian apoptosis and yeast programmed cell death (PCD) share a variety of features including reactive oxygen species production, protease activity and a major role played by mitochondria. In view of this, and of the distinctive characteristics differentiating yeast and multicellular organism PCD, the mitochondrial contribution to cell death in the genetically tractable yeast Saccharomyces cerevisiae has been intensively investigated. In this mini-review we report whether and how yeast mitochondrial function and proteins belonging to oxidative phosphorylation, protein trafficking into and out of mitochondria, and mitochondrial dynamics, play a role in PCD. Since in PCD many processes take place over time, emphasis will be placed on an experimental model based on acetic acid-induced PCD (AA-PCD) which has the unique feature of having been investigated as a function of time. As will be described there are at least two AA-PCD pathways each with a multifaceted role played by mitochondrial components, in particular by cytochrome c.
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spelling pubmed-33885952012-07-10 The role of mitochondria in yeast programmed cell death Guaragnella, Nicoletta Ždralević, Maša Antonacci, Lucia Passarella, Salvatore Marra, Ersilia Giannattasio, Sergio Front Oncol Oncology Mammalian apoptosis and yeast programmed cell death (PCD) share a variety of features including reactive oxygen species production, protease activity and a major role played by mitochondria. In view of this, and of the distinctive characteristics differentiating yeast and multicellular organism PCD, the mitochondrial contribution to cell death in the genetically tractable yeast Saccharomyces cerevisiae has been intensively investigated. In this mini-review we report whether and how yeast mitochondrial function and proteins belonging to oxidative phosphorylation, protein trafficking into and out of mitochondria, and mitochondrial dynamics, play a role in PCD. Since in PCD many processes take place over time, emphasis will be placed on an experimental model based on acetic acid-induced PCD (AA-PCD) which has the unique feature of having been investigated as a function of time. As will be described there are at least two AA-PCD pathways each with a multifaceted role played by mitochondrial components, in particular by cytochrome c. Frontiers Research Foundation 2012-07-03 /pmc/articles/PMC3388595/ /pubmed/22783546 http://dx.doi.org/10.3389/fonc.2012.00070 Text en Copyright © Guaragnella, Ždralević, Antonacci, Passarella, Marra and Giannattasio. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) , which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Oncology
Guaragnella, Nicoletta
Ždralević, Maša
Antonacci, Lucia
Passarella, Salvatore
Marra, Ersilia
Giannattasio, Sergio
The role of mitochondria in yeast programmed cell death
title The role of mitochondria in yeast programmed cell death
title_full The role of mitochondria in yeast programmed cell death
title_fullStr The role of mitochondria in yeast programmed cell death
title_full_unstemmed The role of mitochondria in yeast programmed cell death
title_short The role of mitochondria in yeast programmed cell death
title_sort role of mitochondria in yeast programmed cell death
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388595/
https://www.ncbi.nlm.nih.gov/pubmed/22783546
http://dx.doi.org/10.3389/fonc.2012.00070
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