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The Effect of Neural Noise on Spike Time Precision in a Detailed CA3 Neuron Model

Experimental and computational studies emphasize the role of the millisecond precision of neuronal spike times as an important coding mechanism for transmitting and representing information in the central nervous system. We investigate the spike time precision of a multicompartmental pyramidal neuro...

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Autores principales: Kuriscak, Eduard, Marsalek, Petr, Stroffek, Julius, Wünsch, Zdenek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388596/
https://www.ncbi.nlm.nih.gov/pubmed/22778784
http://dx.doi.org/10.1155/2012/595398
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author Kuriscak, Eduard
Marsalek, Petr
Stroffek, Julius
Wünsch, Zdenek
author_facet Kuriscak, Eduard
Marsalek, Petr
Stroffek, Julius
Wünsch, Zdenek
author_sort Kuriscak, Eduard
collection PubMed
description Experimental and computational studies emphasize the role of the millisecond precision of neuronal spike times as an important coding mechanism for transmitting and representing information in the central nervous system. We investigate the spike time precision of a multicompartmental pyramidal neuron model of the CA3 region of the hippocampus under the influence of various sources of neuronal noise. We describe differences in the contribution to noise originating from voltage-gated ion channels, synaptic vesicle release, and vesicle quantal size. We analyze the effect of interspike intervals and the voltage course preceding the firing of spikes on the spike-timing jitter. The main finding of this study is the ranking of different noise sources according to their contribution to spike time precision. The most influential is synaptic vesicle release noise, causing the spike jitter to vary from 1 ms to 7 ms of a mean value 2.5 ms. Of second importance was the noise incurred by vesicle quantal size variation causing the spike time jitter to vary from 0.03 ms to 0.6 ms. Least influential was the voltage-gated channel noise generating spike jitter from 0.02 ms to 0.15 ms.
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spelling pubmed-33885962012-07-09 The Effect of Neural Noise on Spike Time Precision in a Detailed CA3 Neuron Model Kuriscak, Eduard Marsalek, Petr Stroffek, Julius Wünsch, Zdenek Comput Math Methods Med Research Article Experimental and computational studies emphasize the role of the millisecond precision of neuronal spike times as an important coding mechanism for transmitting and representing information in the central nervous system. We investigate the spike time precision of a multicompartmental pyramidal neuron model of the CA3 region of the hippocampus under the influence of various sources of neuronal noise. We describe differences in the contribution to noise originating from voltage-gated ion channels, synaptic vesicle release, and vesicle quantal size. We analyze the effect of interspike intervals and the voltage course preceding the firing of spikes on the spike-timing jitter. The main finding of this study is the ranking of different noise sources according to their contribution to spike time precision. The most influential is synaptic vesicle release noise, causing the spike jitter to vary from 1 ms to 7 ms of a mean value 2.5 ms. Of second importance was the noise incurred by vesicle quantal size variation causing the spike time jitter to vary from 0.03 ms to 0.6 ms. Least influential was the voltage-gated channel noise generating spike jitter from 0.02 ms to 0.15 ms. Hindawi Publishing Corporation 2012 2012-06-24 /pmc/articles/PMC3388596/ /pubmed/22778784 http://dx.doi.org/10.1155/2012/595398 Text en Copyright © 2012 Eduard Kuriscak et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kuriscak, Eduard
Marsalek, Petr
Stroffek, Julius
Wünsch, Zdenek
The Effect of Neural Noise on Spike Time Precision in a Detailed CA3 Neuron Model
title The Effect of Neural Noise on Spike Time Precision in a Detailed CA3 Neuron Model
title_full The Effect of Neural Noise on Spike Time Precision in a Detailed CA3 Neuron Model
title_fullStr The Effect of Neural Noise on Spike Time Precision in a Detailed CA3 Neuron Model
title_full_unstemmed The Effect of Neural Noise on Spike Time Precision in a Detailed CA3 Neuron Model
title_short The Effect of Neural Noise on Spike Time Precision in a Detailed CA3 Neuron Model
title_sort effect of neural noise on spike time precision in a detailed ca3 neuron model
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388596/
https://www.ncbi.nlm.nih.gov/pubmed/22778784
http://dx.doi.org/10.1155/2012/595398
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