Finding new therapies for sepsis: the need for patient stratification and the use of genetic biomarkers

Reversing the immunoparalysis associated with septic shock remains a priority for improving the outcome of patients suffering from sepsis. The efficacy of future therapies may be better studied under an effective system of patient stratification. Gene expression biomarkers offer a mechanism by which...

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Detalles Bibliográficos
Autores principales: Hobson, Michael J, Wong, Hector R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388659/
https://www.ncbi.nlm.nih.gov/pubmed/22169064
http://dx.doi.org/10.1186/cc10527
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author Hobson, Michael J
Wong, Hector R
author_facet Hobson, Michael J
Wong, Hector R
author_sort Hobson, Michael J
collection PubMed
description Reversing the immunoparalysis associated with septic shock remains a priority for improving the outcome of patients suffering from sepsis. The efficacy of future therapies may be better studied under an effective system of patient stratification. Gene expression biomarkers offer a mechanism by which patients may be appropriately stratified in such clinical trials.
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spelling pubmed-33886592012-12-07 Finding new therapies for sepsis: the need for patient stratification and the use of genetic biomarkers Hobson, Michael J Wong, Hector R Crit Care Commentary Reversing the immunoparalysis associated with septic shock remains a priority for improving the outcome of patients suffering from sepsis. The efficacy of future therapies may be better studied under an effective system of patient stratification. Gene expression biomarkers offer a mechanism by which patients may be appropriately stratified in such clinical trials. BioMed Central 2011 2011-12-07 /pmc/articles/PMC3388659/ /pubmed/22169064 http://dx.doi.org/10.1186/cc10527 Text en Copyright ©2011 BioMed Central Ltd
spellingShingle Commentary
Hobson, Michael J
Wong, Hector R
Finding new therapies for sepsis: the need for patient stratification and the use of genetic biomarkers
title Finding new therapies for sepsis: the need for patient stratification and the use of genetic biomarkers
title_full Finding new therapies for sepsis: the need for patient stratification and the use of genetic biomarkers
title_fullStr Finding new therapies for sepsis: the need for patient stratification and the use of genetic biomarkers
title_full_unstemmed Finding new therapies for sepsis: the need for patient stratification and the use of genetic biomarkers
title_short Finding new therapies for sepsis: the need for patient stratification and the use of genetic biomarkers
title_sort finding new therapies for sepsis: the need for patient stratification and the use of genetic biomarkers
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388659/
https://www.ncbi.nlm.nih.gov/pubmed/22169064
http://dx.doi.org/10.1186/cc10527
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