Regioselective chlorination and bromination of unprotected anilines under mild conditions using copper halides in ionic liquids

By using ionic liquids as solvents, the chlorination or bromination of unprotected anilines at the para-position can be achieved in high yields with copper halides under mild conditions, without the need for potentially hazardous operations such as supplementing oxygen or gaseous HCl.

Detalles Bibliográficos
Autores principales: Wang, Han, Wen, Kun, Nurahmat, Nurbiya, Shao, Yan, Zhang, He, Wei, Chao, Li, Ya, Shen, Yongjia, Sun, Zhihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2012
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388862/
https://www.ncbi.nlm.nih.gov/pubmed/23015822
http://dx.doi.org/10.3762/bjoc.8.84
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author Wang, Han
Wen, Kun
Nurahmat, Nurbiya
Shao, Yan
Zhang, He
Wei, Chao
Li, Ya
Shen, Yongjia
Sun, Zhihua
author_facet Wang, Han
Wen, Kun
Nurahmat, Nurbiya
Shao, Yan
Zhang, He
Wei, Chao
Li, Ya
Shen, Yongjia
Sun, Zhihua
author_sort Wang, Han
collection PubMed
description By using ionic liquids as solvents, the chlorination or bromination of unprotected anilines at the para-position can be achieved in high yields with copper halides under mild conditions, without the need for potentially hazardous operations such as supplementing oxygen or gaseous HCl.
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spelling pubmed-33888622012-09-26 Regioselective chlorination and bromination of unprotected anilines under mild conditions using copper halides in ionic liquids Wang, Han Wen, Kun Nurahmat, Nurbiya Shao, Yan Zhang, He Wei, Chao Li, Ya Shen, Yongjia Sun, Zhihua Beilstein J Org Chem Full Research Paper By using ionic liquids as solvents, the chlorination or bromination of unprotected anilines at the para-position can be achieved in high yields with copper halides under mild conditions, without the need for potentially hazardous operations such as supplementing oxygen or gaseous HCl. Beilstein-Institut 2012-05-16 /pmc/articles/PMC3388862/ /pubmed/23015822 http://dx.doi.org/10.3762/bjoc.8.84 Text en Copyright © 2012, Wang et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Wang, Han
Wen, Kun
Nurahmat, Nurbiya
Shao, Yan
Zhang, He
Wei, Chao
Li, Ya
Shen, Yongjia
Sun, Zhihua
Regioselective chlorination and bromination of unprotected anilines under mild conditions using copper halides in ionic liquids
title Regioselective chlorination and bromination of unprotected anilines under mild conditions using copper halides in ionic liquids
title_full Regioselective chlorination and bromination of unprotected anilines under mild conditions using copper halides in ionic liquids
title_fullStr Regioselective chlorination and bromination of unprotected anilines under mild conditions using copper halides in ionic liquids
title_full_unstemmed Regioselective chlorination and bromination of unprotected anilines under mild conditions using copper halides in ionic liquids
title_short Regioselective chlorination and bromination of unprotected anilines under mild conditions using copper halides in ionic liquids
title_sort regioselective chlorination and bromination of unprotected anilines under mild conditions using copper halides in ionic liquids
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388862/
https://www.ncbi.nlm.nih.gov/pubmed/23015822
http://dx.doi.org/10.3762/bjoc.8.84
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