Identification and isolation of insecticidal oxazoles from Pseudomonas spp.

Two new and five known oxazoles were identified from two different Pseudomonas strains in addition to the known pyrones pseudopyronine A and B. Labeling experiments confirmed their structures and gave initial evidence for a novel biosynthesis pathway of these natural oxazoles. In order to confirm th...

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Autores principales: Grundmann, Florian, Dill, Veronika, Dowling, Andrea, Thanwisai, Aunchalee, Bode, Edna, Chantratita, Narisara, ffrench-Constant, Richard, Bode, Helge B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2012
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388863/
https://www.ncbi.nlm.nih.gov/pubmed/23015823
http://dx.doi.org/10.3762/bjoc.8.85
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author Grundmann, Florian
Dill, Veronika
Dowling, Andrea
Thanwisai, Aunchalee
Bode, Edna
Chantratita, Narisara
ffrench-Constant, Richard
Bode, Helge B
author_facet Grundmann, Florian
Dill, Veronika
Dowling, Andrea
Thanwisai, Aunchalee
Bode, Edna
Chantratita, Narisara
ffrench-Constant, Richard
Bode, Helge B
author_sort Grundmann, Florian
collection PubMed
description Two new and five known oxazoles were identified from two different Pseudomonas strains in addition to the known pyrones pseudopyronine A and B. Labeling experiments confirmed their structures and gave initial evidence for a novel biosynthesis pathway of these natural oxazoles. In order to confirm their structure, they were synthesized, which also allowed tests of their bioactivity. Additionally, the bioactivities of the synthesis intermediates were also investigated revealing interesting biological activities for several compounds despite their overall simple structures.
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spelling pubmed-33888632012-09-26 Identification and isolation of insecticidal oxazoles from Pseudomonas spp. Grundmann, Florian Dill, Veronika Dowling, Andrea Thanwisai, Aunchalee Bode, Edna Chantratita, Narisara ffrench-Constant, Richard Bode, Helge B Beilstein J Org Chem Letter Two new and five known oxazoles were identified from two different Pseudomonas strains in addition to the known pyrones pseudopyronine A and B. Labeling experiments confirmed their structures and gave initial evidence for a novel biosynthesis pathway of these natural oxazoles. In order to confirm their structure, they were synthesized, which also allowed tests of their bioactivity. Additionally, the bioactivities of the synthesis intermediates were also investigated revealing interesting biological activities for several compounds despite their overall simple structures. Beilstein-Institut 2012-05-18 /pmc/articles/PMC3388863/ /pubmed/23015823 http://dx.doi.org/10.3762/bjoc.8.85 Text en Copyright © 2012, Grundmann et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Letter
Grundmann, Florian
Dill, Veronika
Dowling, Andrea
Thanwisai, Aunchalee
Bode, Edna
Chantratita, Narisara
ffrench-Constant, Richard
Bode, Helge B
Identification and isolation of insecticidal oxazoles from Pseudomonas spp.
title Identification and isolation of insecticidal oxazoles from Pseudomonas spp.
title_full Identification and isolation of insecticidal oxazoles from Pseudomonas spp.
title_fullStr Identification and isolation of insecticidal oxazoles from Pseudomonas spp.
title_full_unstemmed Identification and isolation of insecticidal oxazoles from Pseudomonas spp.
title_short Identification and isolation of insecticidal oxazoles from Pseudomonas spp.
title_sort identification and isolation of insecticidal oxazoles from pseudomonas spp.
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388863/
https://www.ncbi.nlm.nih.gov/pubmed/23015823
http://dx.doi.org/10.3762/bjoc.8.85
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