An intramolecular inverse electron demand Diels–Alder approach to annulated α-carbolines

Intramolecular inverse electron demand cycloadditions of isatin-derived 1,2,4-triazines with acetylenic dienophiles tethered by amidations or transesterifications proceed in excellent yields to produce lactam- or lactone-fused α-carbolines. Beginning with various isatins and alkynyl dienophiles, a p...

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Detalles Bibliográficos
Autores principales: Ma, Zhiyuan, Ni, Feng, Woo, Grace H C, Lo, Sie-Mun, Roveto, Philip M, Schaus, Scott E, Snyder, John K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2012
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388871/
https://www.ncbi.nlm.nih.gov/pubmed/23015831
http://dx.doi.org/10.3762/bjoc.8.93
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author Ma, Zhiyuan
Ni, Feng
Woo, Grace H C
Lo, Sie-Mun
Roveto, Philip M
Schaus, Scott E
Snyder, John K
author_facet Ma, Zhiyuan
Ni, Feng
Woo, Grace H C
Lo, Sie-Mun
Roveto, Philip M
Schaus, Scott E
Snyder, John K
author_sort Ma, Zhiyuan
collection PubMed
description Intramolecular inverse electron demand cycloadditions of isatin-derived 1,2,4-triazines with acetylenic dienophiles tethered by amidations or transesterifications proceed in excellent yields to produce lactam- or lactone-fused α-carbolines. Beginning with various isatins and alkynyl dienophiles, a pilot-scale library of eighty-eight α-carbolines was prepared by using this robust methodology for biological evaluation.
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spelling pubmed-33888712012-09-26 An intramolecular inverse electron demand Diels–Alder approach to annulated α-carbolines Ma, Zhiyuan Ni, Feng Woo, Grace H C Lo, Sie-Mun Roveto, Philip M Schaus, Scott E Snyder, John K Beilstein J Org Chem Full Research Paper Intramolecular inverse electron demand cycloadditions of isatin-derived 1,2,4-triazines with acetylenic dienophiles tethered by amidations or transesterifications proceed in excellent yields to produce lactam- or lactone-fused α-carbolines. Beginning with various isatins and alkynyl dienophiles, a pilot-scale library of eighty-eight α-carbolines was prepared by using this robust methodology for biological evaluation. Beilstein-Institut 2012-06-06 /pmc/articles/PMC3388871/ /pubmed/23015831 http://dx.doi.org/10.3762/bjoc.8.93 Text en Copyright © 2012, Ma et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Ma, Zhiyuan
Ni, Feng
Woo, Grace H C
Lo, Sie-Mun
Roveto, Philip M
Schaus, Scott E
Snyder, John K
An intramolecular inverse electron demand Diels–Alder approach to annulated α-carbolines
title An intramolecular inverse electron demand Diels–Alder approach to annulated α-carbolines
title_full An intramolecular inverse electron demand Diels–Alder approach to annulated α-carbolines
title_fullStr An intramolecular inverse electron demand Diels–Alder approach to annulated α-carbolines
title_full_unstemmed An intramolecular inverse electron demand Diels–Alder approach to annulated α-carbolines
title_short An intramolecular inverse electron demand Diels–Alder approach to annulated α-carbolines
title_sort intramolecular inverse electron demand diels–alder approach to annulated α-carbolines
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388871/
https://www.ncbi.nlm.nih.gov/pubmed/23015831
http://dx.doi.org/10.3762/bjoc.8.93
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