Synthesis and characterization of Sant-75 derivatives as Hedgehog-pathway inhibitors

Sant-75 is a newly identified potent inhibitor of the hedgehog pathway. We designed a diversity-oriented synthesis program, and synthesized a series of Sant-75 analogues, which lays the foundation for further investigation of the structure–activity relationship of this important class of hedgehog-pa...

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Detalles Bibliográficos
Autores principales: Che, Chao, Li, Song, Yang, Bo, Xin, Shengchang, Yu, Zhixiong, Shao, Taofeng, Tao, Chuanye, Lin, Shuo, Yang, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2012
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388872/
https://www.ncbi.nlm.nih.gov/pubmed/23015832
http://dx.doi.org/10.3762/bjoc.8.94
Descripción
Sumario:Sant-75 is a newly identified potent inhibitor of the hedgehog pathway. We designed a diversity-oriented synthesis program, and synthesized a series of Sant-75 analogues, which lays the foundation for further investigation of the structure–activity relationship of this important class of hedgehog-pathway inhibitors.

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