Synthesis and characterization of Sant-75 derivatives as Hedgehog-pathway inhibitors

Sant-75 is a newly identified potent inhibitor of the hedgehog pathway. We designed a diversity-oriented synthesis program, and synthesized a series of Sant-75 analogues, which lays the foundation for further investigation of the structure–activity relationship of this important class of hedgehog-pa...

Descripción completa

Detalles Bibliográficos
Autores principales: Che, Chao, Li, Song, Yang, Bo, Xin, Shengchang, Yu, Zhixiong, Shao, Taofeng, Tao, Chuanye, Lin, Shuo, Yang, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2012
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388872/
https://www.ncbi.nlm.nih.gov/pubmed/23015832
http://dx.doi.org/10.3762/bjoc.8.94
_version_ 1782237253190287360
author Che, Chao
Li, Song
Yang, Bo
Xin, Shengchang
Yu, Zhixiong
Shao, Taofeng
Tao, Chuanye
Lin, Shuo
Yang, Zhen
author_facet Che, Chao
Li, Song
Yang, Bo
Xin, Shengchang
Yu, Zhixiong
Shao, Taofeng
Tao, Chuanye
Lin, Shuo
Yang, Zhen
author_sort Che, Chao
collection PubMed
description Sant-75 is a newly identified potent inhibitor of the hedgehog pathway. We designed a diversity-oriented synthesis program, and synthesized a series of Sant-75 analogues, which lays the foundation for further investigation of the structure–activity relationship of this important class of hedgehog-pathway inhibitors.
format Online
Article
Text
id pubmed-3388872
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Beilstein-Institut
record_format MEDLINE/PubMed
spelling pubmed-33888722012-09-26 Synthesis and characterization of Sant-75 derivatives as Hedgehog-pathway inhibitors Che, Chao Li, Song Yang, Bo Xin, Shengchang Yu, Zhixiong Shao, Taofeng Tao, Chuanye Lin, Shuo Yang, Zhen Beilstein J Org Chem Full Research Paper Sant-75 is a newly identified potent inhibitor of the hedgehog pathway. We designed a diversity-oriented synthesis program, and synthesized a series of Sant-75 analogues, which lays the foundation for further investigation of the structure–activity relationship of this important class of hedgehog-pathway inhibitors. Beilstein-Institut 2012-06-06 /pmc/articles/PMC3388872/ /pubmed/23015832 http://dx.doi.org/10.3762/bjoc.8.94 Text en Copyright © 2012, Che et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Che, Chao
Li, Song
Yang, Bo
Xin, Shengchang
Yu, Zhixiong
Shao, Taofeng
Tao, Chuanye
Lin, Shuo
Yang, Zhen
Synthesis and characterization of Sant-75 derivatives as Hedgehog-pathway inhibitors
title Synthesis and characterization of Sant-75 derivatives as Hedgehog-pathway inhibitors
title_full Synthesis and characterization of Sant-75 derivatives as Hedgehog-pathway inhibitors
title_fullStr Synthesis and characterization of Sant-75 derivatives as Hedgehog-pathway inhibitors
title_full_unstemmed Synthesis and characterization of Sant-75 derivatives as Hedgehog-pathway inhibitors
title_short Synthesis and characterization of Sant-75 derivatives as Hedgehog-pathway inhibitors
title_sort synthesis and characterization of sant-75 derivatives as hedgehog-pathway inhibitors
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388872/
https://www.ncbi.nlm.nih.gov/pubmed/23015832
http://dx.doi.org/10.3762/bjoc.8.94
work_keys_str_mv AT chechao synthesisandcharacterizationofsant75derivativesashedgehogpathwayinhibitors
AT lisong synthesisandcharacterizationofsant75derivativesashedgehogpathwayinhibitors
AT yangbo synthesisandcharacterizationofsant75derivativesashedgehogpathwayinhibitors
AT xinshengchang synthesisandcharacterizationofsant75derivativesashedgehogpathwayinhibitors
AT yuzhixiong synthesisandcharacterizationofsant75derivativesashedgehogpathwayinhibitors
AT shaotaofeng synthesisandcharacterizationofsant75derivativesashedgehogpathwayinhibitors
AT taochuanye synthesisandcharacterizationofsant75derivativesashedgehogpathwayinhibitors
AT linshuo synthesisandcharacterizationofsant75derivativesashedgehogpathwayinhibitors
AT yangzhen synthesisandcharacterizationofsant75derivativesashedgehogpathwayinhibitors

Ejemplares similares