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Phosphomannopentaose sulfate (PI-88) suppresses angiogenesis by downregulating heparanase and vascular endothelial growth factor in an oxygen-induced retinal neovascularization animal model

PURPOSE: Vascular endothelial growth factor (VEGF) is the most potent angiogenic mitogen, and has been associated with angiogenesis. Heparanase is an endoglycosidase that specifically cleaves heparan sulfate side chains, which can induce VEGF expression. The aims of the present study were to evaluat...

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Detalles Bibliográficos
Autores principales:	Liang, Xian-Jun, Yuan, Ling, Hu, Jie, Yu, Hong-Hua, Li, Tao, Lin, Shao-Fen, Tang, Shi-Bo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Molecular Vision 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388984/ https://www.ncbi.nlm.nih.gov/pubmed/22773903

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