Mutant NADH dehydrogenase subunit 4 gene delivery to mitochondria by targeting sequence-modified adeno-associated virus induces visual loss and optic atrophy in mice

PURPOSE: Although mutated G11778A NADH ubiquinone oxidoreductase subunit 4 (ND4) mitochondrial DNA (mtDNA) is firmly linked to the blindness of Leber hereditary optic neuropathy (LHON), a bona fide animal model system with mutated mtDNA complex I subunits that would enable probing the pathogenesis o...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Hong, Ozdemir, Sacide S., Koilkonda, Rajeshwari D., Chou, Tsung-Han, Porciatti, Vittorio, Chiodo, Vince, Boye, Sanford L., Hauswirth, William W., Lewin, Alfred S., Guy, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Vision 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388991/
https://www.ncbi.nlm.nih.gov/pubmed/22773905

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388991/
https://www.ncbi.nlm.nih.gov/pubmed/22773905

Ejemplares similares