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Mutant NADH dehydrogenase subunit 4 gene delivery to mitochondria by targeting sequence-modified adeno-associated virus induces visual loss and optic atrophy in mice

PURPOSE: Although mutated G11778A NADH ubiquinone oxidoreductase subunit 4 (ND4) mitochondrial DNA (mtDNA) is firmly linked to the blindness of Leber hereditary optic neuropathy (LHON), a bona fide animal model system with mutated mtDNA complex I subunits that would enable probing the pathogenesis o...

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Detalles Bibliográficos
Autores principales:	Yu, Hong, Ozdemir, Sacide S., Koilkonda, Rajeshwari D., Chou, Tsung-Han, Porciatti, Vittorio, Chiodo, Vince, Boye, Sanford L., Hauswirth, William W., Lewin, Alfred S., Guy, John
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Molecular Vision 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388991/ https://www.ncbi.nlm.nih.gov/pubmed/22773905

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