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A new synthetic chalcone derivative, 2-hydroxy-3',5,5'-trimethoxychalcone (DK-139), suppresses the Toll-like receptor 4-mediated inflammatory response through inhibition of the Akt/NF-κB pathway in BV2 microglial cells

Microglial cells are the resident innate immune cells that sense pathogens and tissue injury in the central nervous system (CNS). Microglial activation is critical for neuroinflammatory responses. The synthetic compound 2-hydroxy-3',5,5'-trimethoxychalcone (DK-139) is a novel chalcone-deri...

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Detalles Bibliográficos
Autores principales:	Lee, Young Han, Jeon, Seung-Hyun, Kim, Se Hyun, Kim, Changyoun, Lee, Seung-Jae, Koh, Dongsoo, Lim, Yoongho, Ha, Kyooseob, Shin, Soon Young
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Society for Biochemistry and Molecular Biology 2012
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389075/ https://www.ncbi.nlm.nih.gov/pubmed/22382990 http://dx.doi.org/10.3858/emm.2012.44.6.042

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