PRR5L degradation promotes MTORC2-mediated PKCδ phosphorylation and cell migration downstream of Gα12

Mammalian target of rapamycin complex (MTORC) 2 phosphorylates AGC protein kinases including PKC and regulates cellular functions including cell migration. However, its regulation remains poorly understood. Here we show that LPA induces two phases of PKCδ hydrophobic motif (HM) phosphorylation. The...

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Detalles Bibliográficos
Autores principales: Gan, Xiaoqing, Wang, Jiyong, Wang, Chen, Sommer, Eeva, Kozasa, Tohru, Srinivasula, Srinivasa, Alessi, Dario, Offermanns, Stefan, Simon, Melvin I., Wu, Dianqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389271/
https://www.ncbi.nlm.nih.gov/pubmed/22609986
http://dx.doi.org/10.1038/ncb2507

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