PAX5-AUTS2: A recurrent fusion gene in childhood B-cell precursor acute lymphoblastic leukemia

PAX5 rearrangements resulting in the expression of fusion transcripts account for 2–3% of childhood B-cell precursor acute lymphoblastic leukemia. Most PAX5 fusions are rare and many of them have only been described in a couple of, or even only in single, cases. We have identified the third case wit...

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Autores principales: Denk, Dagmar, Nebral, Karin, Bradtke, Jutta, Pass, Gertrud, Möricke, Anja, Attarbaschi, Andishe, Strehl, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pergamon Press 2012
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389344/
https://www.ncbi.nlm.nih.gov/pubmed/22578776
http://dx.doi.org/10.1016/j.leukres.2012.04.015
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author Denk, Dagmar
Nebral, Karin
Bradtke, Jutta
Pass, Gertrud
Möricke, Anja
Attarbaschi, Andishe
Strehl, Sabine
author_facet Denk, Dagmar
Nebral, Karin
Bradtke, Jutta
Pass, Gertrud
Möricke, Anja
Attarbaschi, Andishe
Strehl, Sabine
author_sort Denk, Dagmar
collection PubMed
description PAX5 rearrangements resulting in the expression of fusion transcripts account for 2–3% of childhood B-cell precursor acute lymphoblastic leukemia. Most PAX5 fusions are rare and many of them have only been described in a couple of, or even only in single, cases. We have identified the third case with a PAX5-AUTS2 fusion, which results from unbalanced t(7;9)(q11.2;p13.2) rearrangements. Our findings substantiate that PAX5-AUTS2 is a recurrent fusion gene in pediatric B-cell precursor acute lymphoblastic leukemia, and we summarize the clinical characteristics of such patients.
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spelling pubmed-33893442012-08-01 PAX5-AUTS2: A recurrent fusion gene in childhood B-cell precursor acute lymphoblastic leukemia Denk, Dagmar Nebral, Karin Bradtke, Jutta Pass, Gertrud Möricke, Anja Attarbaschi, Andishe Strehl, Sabine Leuk Res Brief Communication PAX5 rearrangements resulting in the expression of fusion transcripts account for 2–3% of childhood B-cell precursor acute lymphoblastic leukemia. Most PAX5 fusions are rare and many of them have only been described in a couple of, or even only in single, cases. We have identified the third case with a PAX5-AUTS2 fusion, which results from unbalanced t(7;9)(q11.2;p13.2) rearrangements. Our findings substantiate that PAX5-AUTS2 is a recurrent fusion gene in pediatric B-cell precursor acute lymphoblastic leukemia, and we summarize the clinical characteristics of such patients. Pergamon Press 2012-08 /pmc/articles/PMC3389344/ /pubmed/22578776 http://dx.doi.org/10.1016/j.leukres.2012.04.015 Text en © 2012 Elsevier Ltd. https://creativecommons.org/licenses/by-nc-nd/3.0/ Open Access under CC BY-NC-ND 3.0 (https://creativecommons.org/licenses/by-nc-nd/3.0/) license
spellingShingle Brief Communication
Denk, Dagmar
Nebral, Karin
Bradtke, Jutta
Pass, Gertrud
Möricke, Anja
Attarbaschi, Andishe
Strehl, Sabine
PAX5-AUTS2: A recurrent fusion gene in childhood B-cell precursor acute lymphoblastic leukemia
title PAX5-AUTS2: A recurrent fusion gene in childhood B-cell precursor acute lymphoblastic leukemia
title_full PAX5-AUTS2: A recurrent fusion gene in childhood B-cell precursor acute lymphoblastic leukemia
title_fullStr PAX5-AUTS2: A recurrent fusion gene in childhood B-cell precursor acute lymphoblastic leukemia
title_full_unstemmed PAX5-AUTS2: A recurrent fusion gene in childhood B-cell precursor acute lymphoblastic leukemia
title_short PAX5-AUTS2: A recurrent fusion gene in childhood B-cell precursor acute lymphoblastic leukemia
title_sort pax5-auts2: a recurrent fusion gene in childhood b-cell precursor acute lymphoblastic leukemia
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389344/
https://www.ncbi.nlm.nih.gov/pubmed/22578776
http://dx.doi.org/10.1016/j.leukres.2012.04.015
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