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The Influence of Human Leukocyte Antigen and IL-10 Gene Polymorphisms on Hepatitis B Virus Outcome

CONTEXT: The clinical outcome of hepatitis B virus (HBV) infection is variable, ranging from spontaneous recovery to an inactive carrier state, chronic hepatitis, occult HBV infection, liver cirrhosis, or hepatocellular carcinoma. EVIDENCE ACQUISITION: This variable pattern and clinical outcomes of...

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Autores principales: Ramezani, Amitis, Banifazl, Mohammad, Mamishi, Setareh, Sofian, Masoomeh, Eslamifar, Ali, Aghakhani, Arezoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kowsar 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389357/
https://www.ncbi.nlm.nih.gov/pubmed/22783343
http://dx.doi.org/10.5812/hepatmon.6094
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author Ramezani, Amitis
Banifazl, Mohammad
Mamishi, Setareh
Sofian, Masoomeh
Eslamifar, Ali
Aghakhani, Arezoo
author_facet Ramezani, Amitis
Banifazl, Mohammad
Mamishi, Setareh
Sofian, Masoomeh
Eslamifar, Ali
Aghakhani, Arezoo
author_sort Ramezani, Amitis
collection PubMed
description CONTEXT: The clinical outcome of hepatitis B virus (HBV) infection is variable, ranging from spontaneous recovery to an inactive carrier state, chronic hepatitis, occult HBV infection, liver cirrhosis, or hepatocellular carcinoma. EVIDENCE ACQUISITION: This variable pattern and clinical outcomes of the infection were mainly determined by virological and host genetic factors. Since the most of host genetic factors associated with HBV infection have currently focused on human leukocyte antigen (HLA) associations and interleukin (IL)-10 gene polymorphisms, this review focuses on the recent progresses in these issues to provide prognostic markers for the outcome of HBV infection. RESULTS: A study on serum levels of IL-10 in occult HBV infected patients reported that the higher level of IL-10 production may suppress function of the immune system against HBV in patients with occult HBV infection. IL-10 promoter polymorphism at position -592 is associated with susceptibility to occult HBV infection. CONCLUSIONS: Findings of this study suggest that the host HLA polymorphism is an important factor in determining outcome of HBV infection but regarding IL-10 gene promoter polymorphisms, we are still have a long way to achieve a definite conclusion.
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spelling pubmed-33893572012-07-10 The Influence of Human Leukocyte Antigen and IL-10 Gene Polymorphisms on Hepatitis B Virus Outcome Ramezani, Amitis Banifazl, Mohammad Mamishi, Setareh Sofian, Masoomeh Eslamifar, Ali Aghakhani, Arezoo Hepat Mon Review Article CONTEXT: The clinical outcome of hepatitis B virus (HBV) infection is variable, ranging from spontaneous recovery to an inactive carrier state, chronic hepatitis, occult HBV infection, liver cirrhosis, or hepatocellular carcinoma. EVIDENCE ACQUISITION: This variable pattern and clinical outcomes of the infection were mainly determined by virological and host genetic factors. Since the most of host genetic factors associated with HBV infection have currently focused on human leukocyte antigen (HLA) associations and interleukin (IL)-10 gene polymorphisms, this review focuses on the recent progresses in these issues to provide prognostic markers for the outcome of HBV infection. RESULTS: A study on serum levels of IL-10 in occult HBV infected patients reported that the higher level of IL-10 production may suppress function of the immune system against HBV in patients with occult HBV infection. IL-10 promoter polymorphism at position -592 is associated with susceptibility to occult HBV infection. CONCLUSIONS: Findings of this study suggest that the host HLA polymorphism is an important factor in determining outcome of HBV infection but regarding IL-10 gene promoter polymorphisms, we are still have a long way to achieve a definite conclusion. Kowsar 2012-05 2012-05-30 /pmc/articles/PMC3389357/ /pubmed/22783343 http://dx.doi.org/10.5812/hepatmon.6094 Text en Copyright © 2012, Kowsar Corp. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Ramezani, Amitis
Banifazl, Mohammad
Mamishi, Setareh
Sofian, Masoomeh
Eslamifar, Ali
Aghakhani, Arezoo
The Influence of Human Leukocyte Antigen and IL-10 Gene Polymorphisms on Hepatitis B Virus Outcome
title The Influence of Human Leukocyte Antigen and IL-10 Gene Polymorphisms on Hepatitis B Virus Outcome
title_full The Influence of Human Leukocyte Antigen and IL-10 Gene Polymorphisms on Hepatitis B Virus Outcome
title_fullStr The Influence of Human Leukocyte Antigen and IL-10 Gene Polymorphisms on Hepatitis B Virus Outcome
title_full_unstemmed The Influence of Human Leukocyte Antigen and IL-10 Gene Polymorphisms on Hepatitis B Virus Outcome
title_short The Influence of Human Leukocyte Antigen and IL-10 Gene Polymorphisms on Hepatitis B Virus Outcome
title_sort influence of human leukocyte antigen and il-10 gene polymorphisms on hepatitis b virus outcome
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389357/
https://www.ncbi.nlm.nih.gov/pubmed/22783343
http://dx.doi.org/10.5812/hepatmon.6094
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