Cargando…

Histamine and motivation

Brain histamine may affect a variety of different behavioral and physiological functions; however, its role in promoting wakefulness has overshadowed its other important functions. Here, we review evidence indicating that brain histamine plays a central role in motivation and emphasize its different...

Descripción completa

Detalles Bibliográficos
Autores principales: Torrealba, Fernando, Riveros, Maria E., Contreras, Marco, Valdes, Jose L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389384/
https://www.ncbi.nlm.nih.gov/pubmed/22783171
http://dx.doi.org/10.3389/fnsys.2012.00051
_version_ 1782237302419881984
author Torrealba, Fernando
Riveros, Maria E.
Contreras, Marco
Valdes, Jose L.
author_facet Torrealba, Fernando
Riveros, Maria E.
Contreras, Marco
Valdes, Jose L.
author_sort Torrealba, Fernando
collection PubMed
description Brain histamine may affect a variety of different behavioral and physiological functions; however, its role in promoting wakefulness has overshadowed its other important functions. Here, we review evidence indicating that brain histamine plays a central role in motivation and emphasize its differential involvement in the appetitive and consummatory phases of motivated behaviors. We discuss the inputs that control histaminergic neurons of the tuberomamillary nucleus (TMN) of the hypothalamus, which determine the distinct role of these neurons in appetitive behavior, sleep/wake cycles, and food anticipatory responses. Moreover, we review evidence supporting the dysfunction of histaminergic neurons and the cortical input of histamine in regulating specific forms of decreased motivation (apathy). In addition, we discuss the relationship between the histamine system and drug addiction in the context of motivation.
format Online
Article
Text
id pubmed-3389384
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-33893842012-07-10 Histamine and motivation Torrealba, Fernando Riveros, Maria E. Contreras, Marco Valdes, Jose L. Front Syst Neurosci Neuroscience Brain histamine may affect a variety of different behavioral and physiological functions; however, its role in promoting wakefulness has overshadowed its other important functions. Here, we review evidence indicating that brain histamine plays a central role in motivation and emphasize its differential involvement in the appetitive and consummatory phases of motivated behaviors. We discuss the inputs that control histaminergic neurons of the tuberomamillary nucleus (TMN) of the hypothalamus, which determine the distinct role of these neurons in appetitive behavior, sleep/wake cycles, and food anticipatory responses. Moreover, we review evidence supporting the dysfunction of histaminergic neurons and the cortical input of histamine in regulating specific forms of decreased motivation (apathy). In addition, we discuss the relationship between the histamine system and drug addiction in the context of motivation. Frontiers Media S.A. 2012-07-04 /pmc/articles/PMC3389384/ /pubmed/22783171 http://dx.doi.org/10.3389/fnsys.2012.00051 Text en Copyright © 2012 Torrealba, Riveros, Contreras and Valdes. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Neuroscience
Torrealba, Fernando
Riveros, Maria E.
Contreras, Marco
Valdes, Jose L.
Histamine and motivation
title Histamine and motivation
title_full Histamine and motivation
title_fullStr Histamine and motivation
title_full_unstemmed Histamine and motivation
title_short Histamine and motivation
title_sort histamine and motivation
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389384/
https://www.ncbi.nlm.nih.gov/pubmed/22783171
http://dx.doi.org/10.3389/fnsys.2012.00051
work_keys_str_mv AT torrealbafernando histamineandmotivation
AT riverosmariae histamineandmotivation
AT contrerasmarco histamineandmotivation
AT valdesjosel histamineandmotivation