The relationship between vitamin D and chemotherapy-induced toxicity – a pilot study

BACKGROUND: There are anecdotal data that lower levels of vitamin D may be associated with increased levels of toxicity in individuals receiving chemotherapy; we therefore wished to investigate this further. METHODS: From a cohort of over 11 000 individuals, we included those who had vitamin D level...

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Autores principales: Kitchen, D, Hughes, B, Gill, I, O'Brien, M, Rumbles, S, Ellis, P, Harper, P, Stebbing, J, Rohatgi, N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389405/
https://www.ncbi.nlm.nih.gov/pubmed/22588559
http://dx.doi.org/10.1038/bjc.2012.194
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author Kitchen, D
Hughes, B
Gill, I
O'Brien, M
Rumbles, S
Ellis, P
Harper, P
Stebbing, J
Rohatgi, N
author_facet Kitchen, D
Hughes, B
Gill, I
O'Brien, M
Rumbles, S
Ellis, P
Harper, P
Stebbing, J
Rohatgi, N
author_sort Kitchen, D
collection PubMed
description BACKGROUND: There are anecdotal data that lower levels of vitamin D may be associated with increased levels of toxicity in individuals receiving chemotherapy; we therefore wished to investigate this further. METHODS: From a cohort of over 11 000 individuals, we included those who had vitamin D levels (serum 1,25(OH)(2)D3) measured before and during chemotherapy. They were analysed for side effects correlating Chemotherapy Toxicity Criteria with vitamin D levels, normalising data for general markers of patient health including C-reactive protein and albumin. RESULTS: A total of 241 (2% of the total cohort) individuals entered the toxicity analysis. We found no overall difference in toxicity effects experienced by patients depending on whether they were vitamin D depleted or had sufficient levels (P=0.78). CONCLUSION: This pilot study suggests routine vitamin D measurement during treatment does not appear to be necessary in the management of chemotherapy-induced toxicity.
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spelling pubmed-33894052013-06-26 The relationship between vitamin D and chemotherapy-induced toxicity – a pilot study Kitchen, D Hughes, B Gill, I O'Brien, M Rumbles, S Ellis, P Harper, P Stebbing, J Rohatgi, N Br J Cancer Short Communication BACKGROUND: There are anecdotal data that lower levels of vitamin D may be associated with increased levels of toxicity in individuals receiving chemotherapy; we therefore wished to investigate this further. METHODS: From a cohort of over 11 000 individuals, we included those who had vitamin D levels (serum 1,25(OH)(2)D3) measured before and during chemotherapy. They were analysed for side effects correlating Chemotherapy Toxicity Criteria with vitamin D levels, normalising data for general markers of patient health including C-reactive protein and albumin. RESULTS: A total of 241 (2% of the total cohort) individuals entered the toxicity analysis. We found no overall difference in toxicity effects experienced by patients depending on whether they were vitamin D depleted or had sufficient levels (P=0.78). CONCLUSION: This pilot study suggests routine vitamin D measurement during treatment does not appear to be necessary in the management of chemotherapy-induced toxicity. Nature Publishing Group 2012-06-26 2012-05-15 /pmc/articles/PMC3389405/ /pubmed/22588559 http://dx.doi.org/10.1038/bjc.2012.194 Text en Copyright © 2012 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Kitchen, D
Hughes, B
Gill, I
O'Brien, M
Rumbles, S
Ellis, P
Harper, P
Stebbing, J
Rohatgi, N
The relationship between vitamin D and chemotherapy-induced toxicity – a pilot study
title The relationship between vitamin D and chemotherapy-induced toxicity – a pilot study
title_full The relationship between vitamin D and chemotherapy-induced toxicity – a pilot study
title_fullStr The relationship between vitamin D and chemotherapy-induced toxicity – a pilot study
title_full_unstemmed The relationship between vitamin D and chemotherapy-induced toxicity – a pilot study
title_short The relationship between vitamin D and chemotherapy-induced toxicity – a pilot study
title_sort relationship between vitamin d and chemotherapy-induced toxicity – a pilot study
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389405/
https://www.ncbi.nlm.nih.gov/pubmed/22588559
http://dx.doi.org/10.1038/bjc.2012.194
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