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Prognosis and prognostic factors of patients with mesothelioma: a population-based study

BACKGROUND: It is important to regularly update survival estimates of patients with malignant mesothelioma as prognosis may vary according to epidemiologic factors and diagnostic and therapeutic management. METHODS: We assessed overall (baseline) survival as well as related prognostic variables in a...

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Autores principales: van der Bij, S, Koffijberg, H, Burgers, J A, Baas, P, van de Vijver, M J, de Mol, B A J M, Moons, K G M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389430/
https://www.ncbi.nlm.nih.gov/pubmed/22644294
http://dx.doi.org/10.1038/bjc.2012.245
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author van der Bij, S
Koffijberg, H
Burgers, J A
Baas, P
van de Vijver, M J
de Mol, B A J M
Moons, K G M
author_facet van der Bij, S
Koffijberg, H
Burgers, J A
Baas, P
van de Vijver, M J
de Mol, B A J M
Moons, K G M
author_sort van der Bij, S
collection PubMed
description BACKGROUND: It is important to regularly update survival estimates of patients with malignant mesothelioma as prognosis may vary according to epidemiologic factors and diagnostic and therapeutic management. METHODS: We assessed overall (baseline) survival as well as related prognostic variables in a large cohort of 1353 patients with a confirmed diagnosis of malignant mesothelioma between 2005 and 2008. RESULTS: About 50% of the patients were 70 years or older at diagnosis and the median latency time since start of asbestos exposure was 49 years. One year after diagnosis, 47% of the patients were alive, 20% after 2 years and 15% after 3 years. Prognostic variables independently associated with worse survival were: older age (HR=1.04 per year 95% CI (1.03–1.06)), sarcomatoid subtype (HR=2.45 95% CI (2.06–2.90)) and non-pleural localisation (HR=1.67 95% CI (1.26–2.22)). CONCLUSION: Survival of patients with malignant mesothelioma is still limited and depends highly on patient age, mesothelioma subtype and localisation. In addition, a substantial part of the patients had a long latency time between asbestos exposure and diagnosis.
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spelling pubmed-33894302013-06-26 Prognosis and prognostic factors of patients with mesothelioma: a population-based study van der Bij, S Koffijberg, H Burgers, J A Baas, P van de Vijver, M J de Mol, B A J M Moons, K G M Br J Cancer Short Communication BACKGROUND: It is important to regularly update survival estimates of patients with malignant mesothelioma as prognosis may vary according to epidemiologic factors and diagnostic and therapeutic management. METHODS: We assessed overall (baseline) survival as well as related prognostic variables in a large cohort of 1353 patients with a confirmed diagnosis of malignant mesothelioma between 2005 and 2008. RESULTS: About 50% of the patients were 70 years or older at diagnosis and the median latency time since start of asbestos exposure was 49 years. One year after diagnosis, 47% of the patients were alive, 20% after 2 years and 15% after 3 years. Prognostic variables independently associated with worse survival were: older age (HR=1.04 per year 95% CI (1.03–1.06)), sarcomatoid subtype (HR=2.45 95% CI (2.06–2.90)) and non-pleural localisation (HR=1.67 95% CI (1.26–2.22)). CONCLUSION: Survival of patients with malignant mesothelioma is still limited and depends highly on patient age, mesothelioma subtype and localisation. In addition, a substantial part of the patients had a long latency time between asbestos exposure and diagnosis. Nature Publishing Group 2012-06-26 2012-05-29 /pmc/articles/PMC3389430/ /pubmed/22644294 http://dx.doi.org/10.1038/bjc.2012.245 Text en Copyright © 2012 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
van der Bij, S
Koffijberg, H
Burgers, J A
Baas, P
van de Vijver, M J
de Mol, B A J M
Moons, K G M
Prognosis and prognostic factors of patients with mesothelioma: a population-based study
title Prognosis and prognostic factors of patients with mesothelioma: a population-based study
title_full Prognosis and prognostic factors of patients with mesothelioma: a population-based study
title_fullStr Prognosis and prognostic factors of patients with mesothelioma: a population-based study
title_full_unstemmed Prognosis and prognostic factors of patients with mesothelioma: a population-based study
title_short Prognosis and prognostic factors of patients with mesothelioma: a population-based study
title_sort prognosis and prognostic factors of patients with mesothelioma: a population-based study
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389430/
https://www.ncbi.nlm.nih.gov/pubmed/22644294
http://dx.doi.org/10.1038/bjc.2012.245
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