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CYP1A1 genotypes and haplotypes and risk of oral cancer: A case-control study in South Indians

The CYP1A1 gene encodes for the enzyme, aryl hydrocarbon hydroxylase, which is involved in the biotransformation of various aromatic tobacco precarcinogens. In the present study, the association between CYP1A1 gene polymorphisms (IVS1-728G > A, Thr461Asn and Ile462Val), and the risk of oral cance...

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Autores principales: Balaji, Lakshmi, Singh, Krishna Balaji, Bhaskar, Lakkakula V.K.S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Genética 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389526/
https://www.ncbi.nlm.nih.gov/pubmed/22888287
http://dx.doi.org/10.1590/S1415-47572012005000024
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author Balaji, Lakshmi
Singh, Krishna Balaji
Bhaskar, Lakkakula V.K.S.
author_facet Balaji, Lakshmi
Singh, Krishna Balaji
Bhaskar, Lakkakula V.K.S.
author_sort Balaji, Lakshmi
collection PubMed
description The CYP1A1 gene encodes for the enzyme, aryl hydrocarbon hydroxylase, which is involved in the biotransformation of various aromatic tobacco precarcinogens. In the present study, the association between CYP1A1 gene polymorphisms (IVS1-728G > A, Thr461Asn and Ile462Val), and the risk of oral cancer, was examined among 157 patients with oral cancer and 132 age-matched controls, in a south Indian population. The strength of the association between CYP1A1 variants and oral cancer was estimated by logistic regression. It was found that Thr461Asn was not polymorphic. Both IVS1-728G > A and Ile462Val frequencies were consistent with Hardy-Weinberg equilibrium in the control group. There were no significant differences in genotype or haplotype frequencies between controls and cases with oral cancer. Hence, CYP1A1 SNPs can be considered as not being associated with oral cancer at either the genotype or haplotype levels in the population studied.
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spelling pubmed-33895262012-08-10 CYP1A1 genotypes and haplotypes and risk of oral cancer: A case-control study in South Indians Balaji, Lakshmi Singh, Krishna Balaji Bhaskar, Lakkakula V.K.S. Genet Mol Biol Human and Medical Genetics The CYP1A1 gene encodes for the enzyme, aryl hydrocarbon hydroxylase, which is involved in the biotransformation of various aromatic tobacco precarcinogens. In the present study, the association between CYP1A1 gene polymorphisms (IVS1-728G > A, Thr461Asn and Ile462Val), and the risk of oral cancer, was examined among 157 patients with oral cancer and 132 age-matched controls, in a south Indian population. The strength of the association between CYP1A1 variants and oral cancer was estimated by logistic regression. It was found that Thr461Asn was not polymorphic. Both IVS1-728G > A and Ile462Val frequencies were consistent with Hardy-Weinberg equilibrium in the control group. There were no significant differences in genotype or haplotype frequencies between controls and cases with oral cancer. Hence, CYP1A1 SNPs can be considered as not being associated with oral cancer at either the genotype or haplotype levels in the population studied. Sociedade Brasileira de Genética 2012 2012-05-10 /pmc/articles/PMC3389526/ /pubmed/22888287 http://dx.doi.org/10.1590/S1415-47572012005000024 Text en Copyright © 2012, Sociedade Brasileira de Genética. License information: This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Human and Medical Genetics
Balaji, Lakshmi
Singh, Krishna Balaji
Bhaskar, Lakkakula V.K.S.
CYP1A1 genotypes and haplotypes and risk of oral cancer: A case-control study in South Indians
title CYP1A1 genotypes and haplotypes and risk of oral cancer: A case-control study in South Indians
title_full CYP1A1 genotypes and haplotypes and risk of oral cancer: A case-control study in South Indians
title_fullStr CYP1A1 genotypes and haplotypes and risk of oral cancer: A case-control study in South Indians
title_full_unstemmed CYP1A1 genotypes and haplotypes and risk of oral cancer: A case-control study in South Indians
title_short CYP1A1 genotypes and haplotypes and risk of oral cancer: A case-control study in South Indians
title_sort cyp1a1 genotypes and haplotypes and risk of oral cancer: a case-control study in south indians
topic Human and Medical Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389526/
https://www.ncbi.nlm.nih.gov/pubmed/22888287
http://dx.doi.org/10.1590/S1415-47572012005000024
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