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Opposite Effects of the S4–S5 Linker and PIP(2) on Voltage-Gated Channel Function: KCNQ1/KCNE1 and Other Channels

Voltage-gated potassium (Kv) channels are tetramers, each subunit presenting six transmembrane segments (S1–S6), with each S1–S4 segments forming a voltage-sensing domain (VSD) and the four S5–S6 forming both the conduction pathway and its gate. S4 segments control the opening of the intracellular a...

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Detalles Bibliográficos
Autores principales:	Choveau, Frank S., Abderemane-Ali, Fayal, Coyan, Fabien C., Es-Salah-Lamoureux, Zeineb, Baró, Isabelle, Loussouarn, Gildas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Research Foundation 2012
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389672/ https://www.ncbi.nlm.nih.gov/pubmed/22787448 http://dx.doi.org/10.3389/fphar.2012.00125

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