Comparison of Soluble Guanylate Cyclase Stimulators and Activators in Models of Cardiovascular Disease Associated with Oxidative Stress

Soluble guanylate cyclase (sGC), the primary mediator of nitric oxide (NO) bioactivity, exists as reduced (NO-sensitive) and oxidized (NO-insensitive) forms. We tested the hypothesis that the cardiovascular protective effects of NO-insensitive sGC activation would be potentiated under conditions of...

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Detalles Bibliográficos
Autores principales: Costell, Melissa H., Ancellin, Nicolas, Bernard, Roberta E., Zhao, Shufang, Upson, John J., Morgan, Lisa A., Maniscalco, Kristeen, Olzinski, Alan R., Ballard, Victoria L. T., Herry, Kenny, Grondin, Pascal, Dodic, Nerina, Mirguet, Olivier, Bouillot, Anne, Gellibert, Francoise, Coatney, Robert W., Lepore, John J., Jucker, Beat M., Jolivette, Larry J., Willette, Robert N., Schnackenberg, Christine G., Behm, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Research Foundation 2012
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389674/
https://www.ncbi.nlm.nih.gov/pubmed/22783192
http://dx.doi.org/10.3389/fphar.2012.00128

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