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Relationship between Serum Lipoprotein Ratios and Insulin Resistance in Polycystic Ovary Syndrome

Objective. To investigate the association between serum lipoprotein ratios and insulin resistance in women with polycystic ovarian syndrome (PCOS). Methods. 105 PCOS patients and 109 controls were randomly enrolled in the study. Serum levels of luteinizing hormone (LH), follicle-stimulating hormone...

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Autores principales: Xiang, Shou-Kui, Hua, Fei, Tang, Ying, Jiang, Xiao-Hong, Zhuang, Qi, Qian, Feng-Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389691/
https://www.ncbi.nlm.nih.gov/pubmed/22792101
http://dx.doi.org/10.1155/2012/173281
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author Xiang, Shou-Kui
Hua, Fei
Tang, Ying
Jiang, Xiao-Hong
Zhuang, Qi
Qian, Feng-Juan
author_facet Xiang, Shou-Kui
Hua, Fei
Tang, Ying
Jiang, Xiao-Hong
Zhuang, Qi
Qian, Feng-Juan
author_sort Xiang, Shou-Kui
collection PubMed
description Objective. To investigate the association between serum lipoprotein ratios and insulin resistance in women with polycystic ovarian syndrome (PCOS). Methods. 105 PCOS patients and 109 controls were randomly enrolled in the study. Serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2), total testosterone (T), fasting glucose (FBG), fasting insulin (FINS), serum triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL-C), and low-density lipoprotein (LDL-C) levels were checked, and then TG/HDL-C ratio, TC/HDL-C, ratio and LDL-C/HDL-C ratio were calculated. The homeostasis model assessment of insulin resistance (HOMA-IR) was used to calculate the insulin resistance. Results. All lipoprotein ratios were significantly higher in PCOS patients as compared to healthy controls (P < 0.05). TG/HDL-C ratio, TC/HDL-C ratio, and LDL-C/HDL-C ratio were significantly correlated with HOMA-IR (P < 0.05). The ROC curve demonstrated that TC/HDL-C ratio had higher sensitivity and specificity in diagnosing PCOS with insulin resistance. Conclusion. This study demonstrates that serum lipoprotein ratio significantly correlates with insulin resistance and can be used as the marker of insulin resistance in PCOS patients.
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spelling pubmed-33896912012-07-12 Relationship between Serum Lipoprotein Ratios and Insulin Resistance in Polycystic Ovary Syndrome Xiang, Shou-Kui Hua, Fei Tang, Ying Jiang, Xiao-Hong Zhuang, Qi Qian, Feng-Juan Int J Endocrinol Research Article Objective. To investigate the association between serum lipoprotein ratios and insulin resistance in women with polycystic ovarian syndrome (PCOS). Methods. 105 PCOS patients and 109 controls were randomly enrolled in the study. Serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol (E2), total testosterone (T), fasting glucose (FBG), fasting insulin (FINS), serum triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL-C), and low-density lipoprotein (LDL-C) levels were checked, and then TG/HDL-C ratio, TC/HDL-C, ratio and LDL-C/HDL-C ratio were calculated. The homeostasis model assessment of insulin resistance (HOMA-IR) was used to calculate the insulin resistance. Results. All lipoprotein ratios were significantly higher in PCOS patients as compared to healthy controls (P < 0.05). TG/HDL-C ratio, TC/HDL-C ratio, and LDL-C/HDL-C ratio were significantly correlated with HOMA-IR (P < 0.05). The ROC curve demonstrated that TC/HDL-C ratio had higher sensitivity and specificity in diagnosing PCOS with insulin resistance. Conclusion. This study demonstrates that serum lipoprotein ratio significantly correlates with insulin resistance and can be used as the marker of insulin resistance in PCOS patients. Hindawi Publishing Corporation 2012 2012-06-25 /pmc/articles/PMC3389691/ /pubmed/22792101 http://dx.doi.org/10.1155/2012/173281 Text en Copyright © 2012 Shou-Kui Xiang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Xiang, Shou-Kui
Hua, Fei
Tang, Ying
Jiang, Xiao-Hong
Zhuang, Qi
Qian, Feng-Juan
Relationship between Serum Lipoprotein Ratios and Insulin Resistance in Polycystic Ovary Syndrome
title Relationship between Serum Lipoprotein Ratios and Insulin Resistance in Polycystic Ovary Syndrome
title_full Relationship between Serum Lipoprotein Ratios and Insulin Resistance in Polycystic Ovary Syndrome
title_fullStr Relationship between Serum Lipoprotein Ratios and Insulin Resistance in Polycystic Ovary Syndrome
title_full_unstemmed Relationship between Serum Lipoprotein Ratios and Insulin Resistance in Polycystic Ovary Syndrome
title_short Relationship between Serum Lipoprotein Ratios and Insulin Resistance in Polycystic Ovary Syndrome
title_sort relationship between serum lipoprotein ratios and insulin resistance in polycystic ovary syndrome
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389691/
https://www.ncbi.nlm.nih.gov/pubmed/22792101
http://dx.doi.org/10.1155/2012/173281
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