PGD Synthase and PGD(2) in Immune Resposne

PGD(2) is formed from arachidonic acid by successive enzyme reactions: oxygenation of arachidonic acid to PGH(2), a common precursor of various prostanoids, catalyzed by cyclooxygenase, and isomerization of PGH(2) to PGD(2) by PGD synthases (PGDSs). PGD(2) can be either pro- or anti-inflammatory dep...

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Detalles Bibliográficos
Autores principales: Joo, Myungsoo, Sadikot, Ruxana T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389719/
https://www.ncbi.nlm.nih.gov/pubmed/22791937
http://dx.doi.org/10.1155/2012/503128
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author Joo, Myungsoo
Sadikot, Ruxana T.
author_facet Joo, Myungsoo
Sadikot, Ruxana T.
author_sort Joo, Myungsoo
collection PubMed
description PGD(2) is formed from arachidonic acid by successive enzyme reactions: oxygenation of arachidonic acid to PGH(2), a common precursor of various prostanoids, catalyzed by cyclooxygenase, and isomerization of PGH(2) to PGD(2) by PGD synthases (PGDSs). PGD(2) can be either pro- or anti-inflammatory depending on disease process and etiology. The anti-inflammatory and immunomodulatory attributes of PGDS/PGD(2) provide opportunities for development of novel therapeutic approaches for resistant infections and refractory inflammatory diseases. This paper highlights the role of PGD synthases and PGD2 in immune inflammatory response.
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spelling pubmed-33897192012-07-12 PGD Synthase and PGD(2) in Immune Resposne Joo, Myungsoo Sadikot, Ruxana T. Mediators Inflamm Review Article PGD(2) is formed from arachidonic acid by successive enzyme reactions: oxygenation of arachidonic acid to PGH(2), a common precursor of various prostanoids, catalyzed by cyclooxygenase, and isomerization of PGH(2) to PGD(2) by PGD synthases (PGDSs). PGD(2) can be either pro- or anti-inflammatory depending on disease process and etiology. The anti-inflammatory and immunomodulatory attributes of PGDS/PGD(2) provide opportunities for development of novel therapeutic approaches for resistant infections and refractory inflammatory diseases. This paper highlights the role of PGD synthases and PGD2 in immune inflammatory response. Hindawi Publishing Corporation 2012 2012-06-25 /pmc/articles/PMC3389719/ /pubmed/22791937 http://dx.doi.org/10.1155/2012/503128 Text en Copyright © 2012 M. Joo and R. T. Sadikot. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Joo, Myungsoo
Sadikot, Ruxana T.
PGD Synthase and PGD(2) in Immune Resposne
title PGD Synthase and PGD(2) in Immune Resposne
title_full PGD Synthase and PGD(2) in Immune Resposne
title_fullStr PGD Synthase and PGD(2) in Immune Resposne
title_full_unstemmed PGD Synthase and PGD(2) in Immune Resposne
title_short PGD Synthase and PGD(2) in Immune Resposne
title_sort pgd synthase and pgd(2) in immune resposne
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389719/
https://www.ncbi.nlm.nih.gov/pubmed/22791937
http://dx.doi.org/10.1155/2012/503128
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