Cargando…

Evaluation of changes in the parameters of brain tissue perfusion in multi-slice computed tomography in patients after carotid artery stenting

BACKGROUND: CT perfusion of the brain allows functional evaluation of cerebral blood flow. Patients with chronic internal carotid artery (ICA) stenosis may suffer from malperfusion. Improvement of cerebral blood flow and remission of neurological symptoms indicate the effectiveness of treatment of i...

Descripción completa

Detalles Bibliográficos
Autores principales: Szarmach, Arkadiusz, Halena, Grzegorz, Buczny, Jacek, Studniarek, Michał, Markiet, Karolina, Szurowska, Edyta, Retkowski, Mariusz, Piskunowicz, Maciej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389933/
https://www.ncbi.nlm.nih.gov/pubmed/22802836
_version_ 1782237378107146240
author Szarmach, Arkadiusz
Halena, Grzegorz
Buczny, Jacek
Studniarek, Michał
Markiet, Karolina
Szurowska, Edyta
Retkowski, Mariusz
Piskunowicz, Maciej
author_facet Szarmach, Arkadiusz
Halena, Grzegorz
Buczny, Jacek
Studniarek, Michał
Markiet, Karolina
Szurowska, Edyta
Retkowski, Mariusz
Piskunowicz, Maciej
author_sort Szarmach, Arkadiusz
collection PubMed
description BACKGROUND: CT perfusion of the brain allows functional evaluation of cerebral blood flow. Patients with chronic internal carotid artery (ICA) stenosis may suffer from malperfusion. Improvement of cerebral blood flow and remission of neurological symptoms indicate the effectiveness of treatment of internal carotid artery stenosis. MATERIAL/METHODS: The aim of the study was to analyze alterations within cerebral perfusion parameters in CT brain perfusion examination in patients who were scheduled for endovascular therapy due to ICA stenosis. Forty patients with ICA stenosis of over 79% who were included in this prospective study underwent perfusion CT examination twice – 24 hours prior to stenting and after 6–8 weeks following the procedure. CBF, CBV, MTT and TTP were evaluated. RESULTS: Prior to endovascular therapy, an increase in MTT and TTP, and a decrease in CBV and CBF were observed within arterial supply of the hemisphere ipsilateral to stenosis. After the procedure, a decrease in MTT and TTP was seen in all cases, while no statistically significant changes of CBF or CBV were observed. MTT proved to be the most sensitive indicator of ICA stenosis, as its values allowed differentiation between critical and non-critical stenosis. No correlation between the degree of ICA stenosis and TTP values was found. Mild cerebral hyperperfusion syndrome (CHS) was observed in only one patient and the difference between pre-treatment MTT values calculated for both hemispheres was shown to be a prognostic factor for CHS incidence. CONCLUSIONS: Endovascular stent placing in patients with hemodynamically significant internal carotid artery stenosis results in alteration of perfusion parameters, especially concerning TTP and MTT.
format Online
Article
Text
id pubmed-3389933
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher International Scientific Literature, Inc.
record_format MEDLINE/PubMed
spelling pubmed-33899332012-07-16 Evaluation of changes in the parameters of brain tissue perfusion in multi-slice computed tomography in patients after carotid artery stenting Szarmach, Arkadiusz Halena, Grzegorz Buczny, Jacek Studniarek, Michał Markiet, Karolina Szurowska, Edyta Retkowski, Mariusz Piskunowicz, Maciej Pol J Radiol Original Article BACKGROUND: CT perfusion of the brain allows functional evaluation of cerebral blood flow. Patients with chronic internal carotid artery (ICA) stenosis may suffer from malperfusion. Improvement of cerebral blood flow and remission of neurological symptoms indicate the effectiveness of treatment of internal carotid artery stenosis. MATERIAL/METHODS: The aim of the study was to analyze alterations within cerebral perfusion parameters in CT brain perfusion examination in patients who were scheduled for endovascular therapy due to ICA stenosis. Forty patients with ICA stenosis of over 79% who were included in this prospective study underwent perfusion CT examination twice – 24 hours prior to stenting and after 6–8 weeks following the procedure. CBF, CBV, MTT and TTP were evaluated. RESULTS: Prior to endovascular therapy, an increase in MTT and TTP, and a decrease in CBV and CBF were observed within arterial supply of the hemisphere ipsilateral to stenosis. After the procedure, a decrease in MTT and TTP was seen in all cases, while no statistically significant changes of CBF or CBV were observed. MTT proved to be the most sensitive indicator of ICA stenosis, as its values allowed differentiation between critical and non-critical stenosis. No correlation between the degree of ICA stenosis and TTP values was found. Mild cerebral hyperperfusion syndrome (CHS) was observed in only one patient and the difference between pre-treatment MTT values calculated for both hemispheres was shown to be a prognostic factor for CHS incidence. CONCLUSIONS: Endovascular stent placing in patients with hemodynamically significant internal carotid artery stenosis results in alteration of perfusion parameters, especially concerning TTP and MTT. International Scientific Literature, Inc. 2011 /pmc/articles/PMC3389933/ /pubmed/22802836 Text en © Pol J Radiol, 2011 This is an open access article. Unrestricted non-commercial use is permitted provided the original work is properly cited.
spellingShingle Original Article
Szarmach, Arkadiusz
Halena, Grzegorz
Buczny, Jacek
Studniarek, Michał
Markiet, Karolina
Szurowska, Edyta
Retkowski, Mariusz
Piskunowicz, Maciej
Evaluation of changes in the parameters of brain tissue perfusion in multi-slice computed tomography in patients after carotid artery stenting
title Evaluation of changes in the parameters of brain tissue perfusion in multi-slice computed tomography in patients after carotid artery stenting
title_full Evaluation of changes in the parameters of brain tissue perfusion in multi-slice computed tomography in patients after carotid artery stenting
title_fullStr Evaluation of changes in the parameters of brain tissue perfusion in multi-slice computed tomography in patients after carotid artery stenting
title_full_unstemmed Evaluation of changes in the parameters of brain tissue perfusion in multi-slice computed tomography in patients after carotid artery stenting
title_short Evaluation of changes in the parameters of brain tissue perfusion in multi-slice computed tomography in patients after carotid artery stenting
title_sort evaluation of changes in the parameters of brain tissue perfusion in multi-slice computed tomography in patients after carotid artery stenting
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389933/
https://www.ncbi.nlm.nih.gov/pubmed/22802836
work_keys_str_mv AT szarmacharkadiusz evaluationofchangesintheparametersofbraintissueperfusioninmultislicecomputedtomographyinpatientsaftercarotidarterystenting
AT halenagrzegorz evaluationofchangesintheparametersofbraintissueperfusioninmultislicecomputedtomographyinpatientsaftercarotidarterystenting
AT bucznyjacek evaluationofchangesintheparametersofbraintissueperfusioninmultislicecomputedtomographyinpatientsaftercarotidarterystenting
AT studniarekmichał evaluationofchangesintheparametersofbraintissueperfusioninmultislicecomputedtomographyinpatientsaftercarotidarterystenting
AT markietkarolina evaluationofchangesintheparametersofbraintissueperfusioninmultislicecomputedtomographyinpatientsaftercarotidarterystenting
AT szurowskaedyta evaluationofchangesintheparametersofbraintissueperfusioninmultislicecomputedtomographyinpatientsaftercarotidarterystenting
AT retkowskimariusz evaluationofchangesintheparametersofbraintissueperfusioninmultislicecomputedtomographyinpatientsaftercarotidarterystenting
AT piskunowiczmaciej evaluationofchangesintheparametersofbraintissueperfusioninmultislicecomputedtomographyinpatientsaftercarotidarterystenting