A Role for siRNA in X-Chromosome Dosage Compensation in Drosophila melanogaster

Sex-chromosome dosage compensation requires selective identification of X chromatin. How this occurs is not fully understood. We show that small interfering RNA (siRNA) mutations enhance the lethality of Drosophila males deficient in X recognition and partially rescue females that inappropriately do...

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Detalles Bibliográficos
Autores principales: Menon, Debashish U., Meller, Victoria H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2012
Materias:
Notes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389965/
https://www.ncbi.nlm.nih.gov/pubmed/22554892
http://dx.doi.org/10.1534/genetics.112.140236
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author Menon, Debashish U.
Meller, Victoria H.
author_facet Menon, Debashish U.
Meller, Victoria H.
author_sort Menon, Debashish U.
collection PubMed
description Sex-chromosome dosage compensation requires selective identification of X chromatin. How this occurs is not fully understood. We show that small interfering RNA (siRNA) mutations enhance the lethality of Drosophila males deficient in X recognition and partially rescue females that inappropriately dosage-compensate. Our findings are consistent with a role for siRNA in selective recognition of X chromatin.
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spelling pubmed-33899652012-08-24 A Role for siRNA in X-Chromosome Dosage Compensation in Drosophila melanogaster Menon, Debashish U. Meller, Victoria H. Genetics Notes Sex-chromosome dosage compensation requires selective identification of X chromatin. How this occurs is not fully understood. We show that small interfering RNA (siRNA) mutations enhance the lethality of Drosophila males deficient in X recognition and partially rescue females that inappropriately dosage-compensate. Our findings are consistent with a role for siRNA in selective recognition of X chromatin. Genetics Society of America 2012-07 /pmc/articles/PMC3389965/ /pubmed/22554892 http://dx.doi.org/10.1534/genetics.112.140236 Text en Copyright © 2012 by the Genetics Society of America Available freely online through the author-supported open access option.
spellingShingle Notes
Menon, Debashish U.
Meller, Victoria H.
A Role for siRNA in X-Chromosome Dosage Compensation in Drosophila melanogaster
title A Role for siRNA in X-Chromosome Dosage Compensation in Drosophila melanogaster
title_full A Role for siRNA in X-Chromosome Dosage Compensation in Drosophila melanogaster
title_fullStr A Role for siRNA in X-Chromosome Dosage Compensation in Drosophila melanogaster
title_full_unstemmed A Role for siRNA in X-Chromosome Dosage Compensation in Drosophila melanogaster
title_short A Role for siRNA in X-Chromosome Dosage Compensation in Drosophila melanogaster
title_sort role for sirna in x-chromosome dosage compensation in drosophila melanogaster
topic Notes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389965/
https://www.ncbi.nlm.nih.gov/pubmed/22554892
http://dx.doi.org/10.1534/genetics.112.140236
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