Cargando…
Effects of Statins on Cardiorenal Syndrome
Cardiovascular disease and renal disease have a close relationship that forms a vicious cycle as a cardiorenal syndrome (CRS). Oxidative stress, endothelial dysfunction, and vascular inflammation could be therapeutic targets when the renin-angiotensin-aldosterone system is activated by accumulation...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390040/ https://www.ncbi.nlm.nih.gov/pubmed/22792467 http://dx.doi.org/10.1155/2012/162545 |
_version_ | 1782237388046598144 |
---|---|
author | Yagi, Shusuke Aihara, Ken-ichi Ikeda, Yasumasa Akaike, Masashi Sata, Masataka Matsumoto, Toshio |
author_facet | Yagi, Shusuke Aihara, Ken-ichi Ikeda, Yasumasa Akaike, Masashi Sata, Masataka Matsumoto, Toshio |
author_sort | Yagi, Shusuke |
collection | PubMed |
description | Cardiovascular disease and renal disease have a close relationship that forms a vicious cycle as a cardiorenal syndrome (CRS). Oxidative stress, endothelial dysfunction, and vascular inflammation could be therapeutic targets when the renin-angiotensin-aldosterone system is activated by accumulation of conventional cardiovascular risk factors; however, a strategy for management of CRS has not been established yet. Statins, HMG-CoA reductase inhibitors, have not only cholesterol-lowering effects but also pleiotropic effects on cardiovascular systems, including anti-inflammatory and antioxidant effects and improvement of nitric oxide bioavailability. Since recent studies have indicated that statins have beneficial effects on chronic kidney disease and heart failure as well as coronary artery disease in cholesterol-lowering-dependent/independent manners, treatment with statins might be a successful strategy for preventing deterioration of CRS. |
format | Online Article Text |
id | pubmed-3390040 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33900402012-07-12 Effects of Statins on Cardiorenal Syndrome Yagi, Shusuke Aihara, Ken-ichi Ikeda, Yasumasa Akaike, Masashi Sata, Masataka Matsumoto, Toshio Int J Vasc Med Review Article Cardiovascular disease and renal disease have a close relationship that forms a vicious cycle as a cardiorenal syndrome (CRS). Oxidative stress, endothelial dysfunction, and vascular inflammation could be therapeutic targets when the renin-angiotensin-aldosterone system is activated by accumulation of conventional cardiovascular risk factors; however, a strategy for management of CRS has not been established yet. Statins, HMG-CoA reductase inhibitors, have not only cholesterol-lowering effects but also pleiotropic effects on cardiovascular systems, including anti-inflammatory and antioxidant effects and improvement of nitric oxide bioavailability. Since recent studies have indicated that statins have beneficial effects on chronic kidney disease and heart failure as well as coronary artery disease in cholesterol-lowering-dependent/independent manners, treatment with statins might be a successful strategy for preventing deterioration of CRS. Hindawi Publishing Corporation 2012 2012-06-26 /pmc/articles/PMC3390040/ /pubmed/22792467 http://dx.doi.org/10.1155/2012/162545 Text en Copyright © 2012 Shusuke Yagi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Yagi, Shusuke Aihara, Ken-ichi Ikeda, Yasumasa Akaike, Masashi Sata, Masataka Matsumoto, Toshio Effects of Statins on Cardiorenal Syndrome |
title | Effects of Statins on Cardiorenal Syndrome |
title_full | Effects of Statins on Cardiorenal Syndrome |
title_fullStr | Effects of Statins on Cardiorenal Syndrome |
title_full_unstemmed | Effects of Statins on Cardiorenal Syndrome |
title_short | Effects of Statins on Cardiorenal Syndrome |
title_sort | effects of statins on cardiorenal syndrome |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390040/ https://www.ncbi.nlm.nih.gov/pubmed/22792467 http://dx.doi.org/10.1155/2012/162545 |
work_keys_str_mv | AT yagishusuke effectsofstatinsoncardiorenalsyndrome AT aiharakenichi effectsofstatinsoncardiorenalsyndrome AT ikedayasumasa effectsofstatinsoncardiorenalsyndrome AT akaikemasashi effectsofstatinsoncardiorenalsyndrome AT satamasataka effectsofstatinsoncardiorenalsyndrome AT matsumototoshio effectsofstatinsoncardiorenalsyndrome |