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Mitochondria and the aging heart
The average human life span has markedly increased in modern society largely attributed to advances in medical and therapeutic sciences that have successfully reduced important health risks. However, advanced age results in numerous alterations to cellular and subcellular components that can impact...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Science Press
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390067/ https://www.ncbi.nlm.nih.gov/pubmed/22783302 http://dx.doi.org/10.3724/SP.J.1263.2011.00159 |
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author | Chaudhary, Ketul R El-Sikhry, Haitham Seubert, John M |
author_facet | Chaudhary, Ketul R El-Sikhry, Haitham Seubert, John M |
author_sort | Chaudhary, Ketul R |
collection | PubMed |
description | The average human life span has markedly increased in modern society largely attributed to advances in medical and therapeutic sciences that have successfully reduced important health risks. However, advanced age results in numerous alterations to cellular and subcellular components that can impact the overall health and function of an individual. Not surprisingly, advanced age is a major risk factor for the development of heart disease in which elderly populations observe increased morbidity and mortality. Even healthy individuals that appear to have normal heart function under resting conditions, actually have an increased susceptibility and vulnerability to stress. This is confounded by the impact that stress and disease can have over time to both the heart and vessels. Although, there is a rapidly growing body of literature investigating the effects of aging on the heart and how age-related alterations affect cardiac function, the biology of aging and underlying mechanisms remain unclear. In this review, we summarize effects of aging on the heart and discuss potential theories of cellular aging with special emphasis on mitochondrial dysfunction. |
format | Online Article Text |
id | pubmed-3390067 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Science Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-33900672012-07-10 Mitochondria and the aging heart Chaudhary, Ketul R El-Sikhry, Haitham Seubert, John M J Geriatr Cardiol Symposium: Review The average human life span has markedly increased in modern society largely attributed to advances in medical and therapeutic sciences that have successfully reduced important health risks. However, advanced age results in numerous alterations to cellular and subcellular components that can impact the overall health and function of an individual. Not surprisingly, advanced age is a major risk factor for the development of heart disease in which elderly populations observe increased morbidity and mortality. Even healthy individuals that appear to have normal heart function under resting conditions, actually have an increased susceptibility and vulnerability to stress. This is confounded by the impact that stress and disease can have over time to both the heart and vessels. Although, there is a rapidly growing body of literature investigating the effects of aging on the heart and how age-related alterations affect cardiac function, the biology of aging and underlying mechanisms remain unclear. In this review, we summarize effects of aging on the heart and discuss potential theories of cellular aging with special emphasis on mitochondrial dysfunction. Science Press 2011-09 /pmc/articles/PMC3390067/ /pubmed/22783302 http://dx.doi.org/10.3724/SP.J.1263.2011.00159 Text en Institute of Geriatric Cardiology http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission. |
spellingShingle | Symposium: Review Chaudhary, Ketul R El-Sikhry, Haitham Seubert, John M Mitochondria and the aging heart |
title | Mitochondria and the aging heart |
title_full | Mitochondria and the aging heart |
title_fullStr | Mitochondria and the aging heart |
title_full_unstemmed | Mitochondria and the aging heart |
title_short | Mitochondria and the aging heart |
title_sort | mitochondria and the aging heart |
topic | Symposium: Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390067/ https://www.ncbi.nlm.nih.gov/pubmed/22783302 http://dx.doi.org/10.3724/SP.J.1263.2011.00159 |
work_keys_str_mv | AT chaudharyketulr mitochondriaandtheagingheart AT elsikhryhaitham mitochondriaandtheagingheart AT seubertjohnm mitochondriaandtheagingheart |